Rnd3

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Rho family GTPase 3
Protein RND3 PDB 1gwn.png
PDB rendering based on 1gwn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RND3 ; ARHE; Rho8; RhoE; memB
External IDs OMIM602924 MGI1921444 HomoloGene21074 GeneCards: RND3 Gene
RNA expression pattern
PBB GE RND3 212724 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 390 74194
Ensembl ENSG00000115963 ENSMUSG00000017144
UniProt P61587 P61588
RefSeq (mRNA) NM_001254738 NM_028810
RefSeq (protein) NP_001241667 NP_083086
Location (UCSC) Chr 2:
151.32 – 151.4 Mb
Chr 2:
51.13 – 51.15 Mb
PubMed search [1] [2]

Rnd3 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND3.[2]

Like other members of the Rho family of Ras-related GTPases it regulates the organization of the actin cytoskeleton in response to extracellular growth factors.

Regulation[edit]

Like Ras, Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998).[supplied by OMIM][2]


Interactions[edit]

Rnd3 has been shown to interact with ARHGAP5[3] and UBXD5.[4]

References[edit]

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823. 
  2. ^ a b "Entrez Gene: RND3 Rho family GTPase 3". 
  3. ^ Wennerberg, Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009. 
  4. ^ Katoh, Hironori; Harada Amane; Mori Kazutoshi; Negishi Manabu (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. (United States) 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653. 

Further reading[edit]