Most episodes of the show follow a central task or event in the daily life of Rob and Big, such as: attempting to break Guinness world records, having their home exorcised, skateboarding, and random things such as buying 12 remote-control helicopters, and Rob's obsession with a net gun. Also, during the show the two of them purchased two animals, a mini horse named "Mini horse" and a bulldog named "Meaty."
A one-hour series finale situated around Rob learning that Big's longtime girlfriend is pregnant, and Big moving out of the house to focus on becoming a father. However, two years later in an interview with friend and fellow MTV star Johnny Knoxville, Dyrdek gave more reasons as to why the show ended.
I think I quit real early, midway through the third season. They taxed us, you can't film reality TV for nine months, it's psycho. I think towards the end it was such was just such a grind that, really, I was ready to move on. It's like, I live on the set. You know what I mean? [The crew] had one room for a control room, [Big Black] had his room, only he didn't live there, so really it was like I lived in a one bedroom with the lights in everywhere, and just dirty from people, and it was like Pee-wee's Playhouse, and I just slowly lost it, you know, was just so sick of it.
Rob & Big returned to MTV with the reality television show, Fantasy Factory, which ran for seven seasons.