|Robert Allan Weinberg|
11 November 1942 |
|Institutions||Massachusetts Institute of Technology
|Doctoral students||Cornelia Bargmann|
|Known for||"The Hallmarks of Cancer" and The biology of cancer|
Robert Allan Weinberg (born 11 November 1942) is a Daniel K. Ludwig Professor for Cancer Research at Massachusetts Institute of Technology (MIT), director of the Ludwig Center of the MIT and American Cancer Society Research Professor; his research is in the area of oncogenes and the genetic basis of human cancer.
Robert Weinberg is also affiliated with the Broad Institute and is a founding member of the Whitehead Institute for Biomedical Research. He co-teaches MIT course 7.012 (introductory biology) with Eric Lander. Weinberg and Lander are among the co-founders of Verastem, biopharmaceutical company focused on discovering and developing drugs to treat cancer by targeting cancer stem cells.
He is best known for his discoveries of the first human oncogene Ras and the first tumor supressor gene Rbp. 371-381, which is partially documented in Natalie Angier′s book, Natural Obsessions, about her year spent in Weinberg's lab.
In the late 20th century, advances in genetics lead to the discovery of over one hundred cancer cell types. Cancer cells were noted for their bewildering diversity. It was hard to identify the principles that cancers had in common.
He and Douglas Hanahan wrote the seminal paper, "The Hallmarks of Cancer", published in January 2000, that gave the six requirements for one renegade cell to cause a deadly cancer: In 2011, they published an updated review article entitled "Hallmarks of cancer: the next generation".
|Self-sufficiency in growth signals||"accelerator pedal stuck on"|
|Insensitivity to anti-growth signals||"brakes don't work"|
|Evading apoptosis||won't die when the body normally would kill the defective cell|
|Limitless replicative potential||infinite generations of descendants|
|Sustained angiogenesis||asking the body to give it a blood supply|
|Tissue invasion and metastasis||migrating and spreading to other organs and tissues|
He won the National Medal of Science and the Keio Medical Science Prize in 1997. In 1999, he received the Albert Einstein World Award of Science in recognition of his valuable and pioneering contributions in the field of Biomedical Sciences and for his productive trajectory related to the genetic and molecular basis of neoplastic disease. He obtained the Wolf Prize in Medicine in 2004 (shared with Roger Y. Tsien), and he is a member of the U.S. National Academy of Sciences. In 2007 he received an honorary doctorate degree in commemoration of Linnaeus from Uppsala University. He is a member of the Royal Swedish Academy of Sciences since 1992. In 2009 he was presented the Hope Funds Award in Basic Research. In 2013 he was awarded the $3 million Breakthrough Prize in Life Sciences for his work.
- Tabin, C.J., Bradley, S.M., Bargmann, C.I., Weinberg, R.A., Papageorge, A.G., Scolnick, E.M., Dhar, R., Lowy, D.R., and Chang, E.H. (1982). "Mechanism of activation of a human oncogene". Nature 300 (5888): 143–149. doi:10.1038/300143a0. PMID 6290897.
- Shih, C. and Weinberg, R.A. (1982). "Isolation of a transforming sequence from a human bladder carcinoma cell line". Cell 29 (1): 161–169. doi:10.1016/0092-8674(82)90100-3. PMID 6286138.
- Hahn, W.C., Counter, C.M., Lundberg, A.S., Beijersbergen, R.L., Brooks, M.W., and Weinberg, R.A. (1999). "Creation of human tumor cells with defined genetic elements". Nature 400 (6743): 464–468. doi:10.1038/22780. PMID 10440377.
- Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA. (2008). "The epithelial-mesenchymal transition generates cells with properties of stem cells". Cell 133 (4): 704–15. doi:10.1016/j.cell.2008.03.027. PMC 2728032. PMID 18485877.
- Weinberg, Robert (2007). The Biology of Cancer. Garland Science (published 2006). ISBN 9780815340768. OCLC 63114199.
Notes and references
- Siddhartha Mukherjee (2010). The Emperor of All Maladies: A Biography of Cancer. Simon & Schuster. ISBN 978-1-4391-0795-9. OCLC 464593321.
- Hanahan, Douglas; Weinberg, RA (January 7, 2000). "The Hallmarks of Cancer". Cell 100 (1): 57–70. doi:10.1016/S0092-8674(00)81683-9. ISSN 0092-8674. PMID 10647931.
- Hanahan, D.; Weinberg, R. A. (2011). "Hallmarks of Cancer: The Next Generation". Cell 144 (5): 646–674. doi:10.1016/j.cell.2011.02.013. PMID 21376230.
- Christine L. Chaffer; Robert A. Weinberg (March 25, 2011). "A perspective on Cancer Cell Metastasis". Science 331 (6024): 1559–1564. doi:10.1126/science.1203543. PMID 21436443.
- "Albert Einstein World Award of Science 1999". Retrieved August 13, 2013.
- "The Royal Swedish Academy of Sciences: Robert Weinberg". Retrieved 2009-09-27.[dead link]
- "LAUREATES 2013". Breakthrough Prize in Lifesciences. Retrieved December 19, 2013.
- Weinberg's page at the Whitehead Institute
- Weinberg's page at MIT
- Weinberg Lab
- Bob Weinberg Playlist Appearance on WMBR's Dinnertime Sampler radio show March 17, 2004
- Weinberg interviewed in American Scientist