In 2009, Söderling made history by becoming the first (and thus far only player) to defeat Rafael Nadal at the French Open. He prevailed in four sets and eventually reached his first grand slam singles final at the event where he lost to then World No. 2 Roger Federer in straight sets, allowing the Swiss to complete a Career Grand Slam in the process. Söderling reached the top ten of the ATP Singles Rankings for the first time in his career later that year and qualified for the year-ending ATP World Tour Finals where he lost in the semi-finals to eventual runner-up, Juan Martín del Potro in three sets. Nonetheless, Söderling finished the year at a then career high of World No. 8.
His good form carried over into 2010 as he reached the semifinals of an ATP Masters 1000 event for the first time at the 2010 BNP Paribas Open where he lost to seventh seed and eventual runner-up Andy Roddick in three sets. In June, Söderling reached his second consecutive final at the French Open, defeating World No. 2 and defending champion Roger Federer for the first time in his career at an ATP level match en route. This win also ended Federer's streak of 23 consecutive semifinal appearances at the grand slams. However, Söderling was not able to cause the same upset he had the previous year, losing to Nadal in straight sets in the final. At the remaining grand slams, Söderling reached the quarterfinals of Wimbledon for the first time in his career where he lost to Nadal in four sets and the quarterfinals of the US Open for the second year in a row where he lost once again to Federer. In November of the same year, Söderling won his first major singles title at the BNP Paribas Masters, defeating Frenchman Gaël Monfils in the final. The win also earned Söderling a new career high singles ranking of World No. 4.
In January 2011, Söderling reached the fourth round of the Australian Open for the first time in his career, but lost to unseeded Ukrainian, Alexandr Dolgopolov in five sets. In February of the same year, Söderling completed a successful title defense for the first time in his career by winning his second consecutive title at the ABN AMRO World Tennis Tournament.
Won tournament; or reached Final; Semifinal; Quarter-final; Round 4, 3, 2, 1; competed at a Round Robin stage; lost in Qualification Round; absent from tournament event; played in a Davis Cup Zonal Group (with its number indication) or Play-off; won a bronze, silver (F or S) or gold medal at the Olympics; a downgraded Masters Series/1000 tournament (Not a Masters Series); or a tournament that was Not Held in a given year.
To avoid confusion and double counting, these charts are updated either at the conclusion of a tournament, or when the player's participation in the tournament has ended.