Roel Nusse

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Roeland "Roel" Nusse
Born (1950-06-09)June 9, 1950
Institutions Stanford University
Alma mater University of Amsterdam, University of California, San Francisco
Academic advisors Harold Varmus

Roeland "Roel" Nusse (born 9 September 1950, Amsterdam) is a Professor at Stanford University and an investigator at the Howard Hughes Medical Institute.[1] His research was seminal in the discovery of Wnt signaling, a family of pleiotropic regulators involved in development and disease.[2]


Nusse received his BSc in biology and his PhD from the University of Amsterdam. Nusse did a postdoctoral fellowship under the guidance of Harold Varmus at the University of California, San Francisco. In 1982, Nusse and Varmus discovered the Wnt1 gene.[3]

After his postdoctural fellowship, Nusse joined the Netherlands Cancer Institute expanding on the earlier work on the Wnt pathway and identifying the pathway in fruit flies. In 1990, he joined the department of Developmental Biology at Stanford University. His lab is currently focused on the role of Wnt in stem cell development and tissue repair.


Professor Nusse received the Peter Debye Prize from the University of Maastricht in 2000. He is a member of the U.S. National Academy of Sciences, European Molecular Biology Organization, and the Royal Dutch Academy of Sciences. He is a fellow of the American Academy of Arts and Sciences.[1]


  1. ^ a b "Roel Nusse". HHMI. Retrieved 6 September 2013. 
  2. ^ Nusse, Roel; Varmus, Harold (22 May 2012). "Three decades of Wnts: a personal perspective on how a scientific field developed". The EMBO Journal 31 (12): 2670–2684. doi:10.1038/emboj.2012.146. 
  3. ^ Nusse, R; Varmus, HE (November 1982). "Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.". Cell 31 (1): 99–109. doi:10.1016/0092-8674(82)90409-3. PMID 6297757.