Catholicism was introduced in the 1530s, and the first diocese was established in 1552. Evangelization among the Indians bore much fruit from the mid-18th to early 19th century, resuming again in 1840. The country declared independence from Spain in 1825. Relations between Church and state are guided by a concordat signed with the Holy See in 1951. Today, Bolivia is a predominantly Catholic country, although the church was disestablished as the state religion in early 2009. There about seven million Catholics out of a total population of nine million.