||It has been suggested that Mean squared error be merged into this article. (Discuss) Proposed since February 2013.|
The root-mean-square deviation (RMSD) or root-mean-square error (RMSE) is a frequently used measure of the differences between values predicted by a model or an estimator and the values actually observed. These individual differences are called residuals when the calculations are performed over the data sample that was used for estimation, and are called prediction errors when computed out-of-sample. The RMSD serves to aggregate the magnitudes of the errors in predictions for various times into a single measure of predictive power. RMSD is a good measure of accuracy, but only to compare forecasting errors of different models for a particular variable and not between variables, as it is scale-dependent.
In some disciplines, the RMSD is used to compare differences between two things that may vary, neither of which is accepted as the "standard". For example, when measuring the average difference between two time series and , the formula becomes
Normalized root-mean-square deviation 
The normalized root-mean-square deviation or error (NRMSD or NRMSE) is the RMSD divided by the range of observed values of a variable being predicted, or:
The value is often expressed as a percentage, where lower values indicate less residual variance.
CV (RMSD) 
- In meteorology, to see how effectively a mathematical model predicts the behavior of the atmosphere
- In bioinformatics, the RMSD is the measure of the average distance between the atoms of superimposed proteins.
- In structure based drug design, the RMSD is a measure of the difference between a crystal conformation of the ligand conformation and a docking prediction.
- In economics, the RMSD is used to determine whether an economic model fits economic indicators. Some experts have argued that RMSD is less reliable than Relative Absolute Error.
- In experimental psychology, the RMSD is used to assess how well models of perception explain the abilities of the human senses.
- In GIS, the RMSD is one measure used to assess the accuracy of spatial analysis and remote sensing.
- In hydrogeology, RMSD and NRMSD are used to evaluate the calibration of a groundwater model.
- In imaging science, the RMSD is part of the peak signal-to-noise ratio, a measure used to assess how well a method to reconstruct an image performs relative to the original image.
- In computational neuroscience, the RMSD is used to assess how well a system learns a given model.
- In Protein nuclear magnetic resonance spectroscopy, the RMSD is used as a measure to estimate the quality of the obtained bundle of structures.
- Submissions for the Netflix Prize were judged using the RMSD from the test dataset's undisclosed "true" values.
- In simulation of energy consumption of buildings, the RMSE and CV(RMSE) are used to calibrate models to measured building performance.
See also 
- Hyndman, Rob J. Koehler, Anne B. (2006). "Another look at measures of forecast accuracy". International Journal of Forecasting: 679–688.
- J. Scott Armstrong and Fred Collopy (1992). "Error Measures For Generalizing About Forecasting Methods: Empirical Comparisons". International Journal of Forecasting 8: 69–80.
- Anderson, M.P.; Woessner, W.W. (1992). Applied Groundwater Modeling: Simulation of Flow and Advective Transport (2nd Edition ed.). Academic Press.
- Ensemble Neural Network Model