Roseophilin

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Roseophilin
Roseophilin.png
Identifiers
CAS number 142386-38-7
PubChem 5467324
ChemSpider 4578301 YesY
ChEMBL CHEMBL1945189
Jmol-3D images Image 1
Properties
Molecular formula C27H33ClN2O2
Molar mass 453.02 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Roseophilin is an antibiotic isolated from Streptomyces griscovirides shown to have antitumor activity.[1] The chemical structure can be considered in terms of two components, a macrotricyclic segment and a heterocyclic side-chain. Several laboratory syntheses of roseophilin (e.g., those of Trost, Furstner, Salamone) are based upon the Paal-Knorr synthesis, and two others are based on the Nazarov cyclization reaction (those of Tius, Frontier).

References[edit]

  1. ^ Furstner, A. (2003). Angew. Chem., Int. Ed. 42 (3582-3603).