Its name came from a misprint of its name in a construction project document Route TW/SK, meaning a road linking Tsuen Wan and Shek Kong. An alternative interpretation is Tsuen Wan Into Shek Kong.
It is the only link to Tai Mo Shan Road, the road leading to Tai Mo Shan, the highest peak in Hong Kong. The last section of Stage 8 of the MacLehose Trail runs along Tai Mo Shan Road. Opposite this intersection is a car park, and the starting point of Stage 9 of the trail, which continues in a westerly direction. Because the road is steep with many bends, vehicles longer than 10 metres are prohibited.
In late 1940's, Route Twisk was built for military use. In early 1960s, Hong Kong Government sought successfully to acquire the road from the British forces and opened it to the public on 25 May 1961.