In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene. It is one of the few investigated polymorphisms of its gene. C267T is a synonymous polymorphism.
As of 2008 meta-analysis of the polymorphism and Alzheimer's disease indicates that there probably is no association between the two, though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease. Another reported association in neuropsychiatry disorders is with treatment response in depression.
C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait self-transcendence. A Japanese study reported no association with personality traits using the NEO PI-R personality inventory.
- "META-ANALYSIS OF ALL PUBLISHED AD ASSOCIATION STUDIES (CASE-CONTROL ONLY) rs1805054". Alzheimer Research Forum. Retrieved 2008-07-04.
- Rui Kan, Binbin Wang, Chuanfang Zhang, Ze Yang, Shun Ji, Zeping Lu, Chenguang Zheng, Feng Jin & Li Wang (November 2004). "Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese". Neuroscience Letters 372 (1): 27–29. doi:10.1016/j.neulet.2004.09.007. PMID 15531082.
- Seung-Hwan Lee, Kang-Joon Lee, Heon-Jeong Lee, Byung-Joo Ham, Seung-Ho Ryu & Min-Soo Lee (April 2005). "Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder". Psychiatry and Clinical Neurosciences 59 (2): 140–145. doi:10.1111/j.1440-1819.2005.01348.x. PMID 15823158.
- Byung-Joo Ham, Yong-Ho Kim, Myung-Jin Choi, Ji-Hyun Cha, Yun-Kyeung Choi & Min-Soo Lee (January 2004). "Serotonergic genes and personality traits in the Korean population". Neuroscience Letters 354 (1): 2–5. doi:10.1016/S0304-3940(03)00753-5. PMID 14698468.
- Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato & Tsukasa Sasaki (July 2006). "No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population". Neuroscience Letters 403 (1–2): 100–102. doi:10.1016/j.neulet.2006.04.020. PMID 16682118.