A music video for the song, directed by Tony T. Datis, made its premiere on Skrillex's YouTube channel on December 23, 2011. In the video, a department store Santa Claus who is addicted to drugs has a panic attack while talking to children. The security then chases Santa to a higher floor of the building where they begin to beat him up. After several seconds of being beaten by the security, Santa appears to gain strength and begins to defend himself. He eventually defeats the gang and runs to an outside balcony, where he kneels down and enjoys the falling snow. At the end of the video his nose begins to bleed.
Data Transmission commented on the track by saying "'Ruffneck (Full Flex)' is a constant barrage of bass sounds, glitchy effects and hard synths. With numerous edits, richly characterful bass and the usual catchiness of his other tracks, Full Flex sees the controversial producer in more familiar territory, packing enormous amounts of detail into every bar."