The single release spent three weeks on the Billboard Hot 100 peaking at #96 during the week of October 28, 1972. The song reached #9 in Canada. The band never recorded a studio version of the song and the hit single version is the live recording from May 22, 1972 which was edited/shortened from 6m24s to 3m27s for AM radio airplay.
The song was covered by Pearl Jam at the Credit Union Centre in Saskatoon, Saskatchewan on September 7, 2005 and then again on September 19, 2011 during their PJ20 Anniversary tour. Eddie Vedder admittedly messed up the lyrics to the song during the first run through of the song in the performance. In order to redeem the band and appeal to the Saskatoon crowd, the band played the song once more before the end of the concert. This time, they invited a fan from the crowd to sing the correct lyrics.
Burton Cummings released "Running Back to Saskatoon" in October 2012 on the album Massey Hall recorded live in Toronto at Massey Hall backed by his band The Carpet Frogs. The album contains many Guess Who and solo hits from his career.