Hubbard was born Ruth Hoffmann in Vienna, Austria and escaped Nazism as a teenager. With her family, she moved to the Boston area and she became a biologist. She graduated from Radcliffe College in 1944, earning an A.B. degree in biochemical sciences. She was married tp Frank Hubbard from 1942 to 1951.
As a research fellow at Harvard in the years after World War II, she worked under George Wald, investigating the biochemistry of retinal and retinol. Wald shared the Nobel Prize in Physiology or Medicine in 1967 for his discoveries about how the eye works. She received a Ph.D. in biology from Radcliffe in 1950, and in 1952, a Guggenheim fellowship at the Carlsberg Laboratory in Copenhagen, Denmark.
During her active research career from the 1940s to the 1960s, she made important contributions to the understanding of the biochemistry and photochemistry of vision in vertebrates and invertebrates. In 1967, she and Wald shared the Paul Karrer Medal for their work in this area.
Social commentary and political activity 
In the late 1960s and early 1970s, Hubbard's interests shifted away from research science toward social and political issues. In her book The Politics of Women's Biology, she wrote that she had been a "devout scientist" from 1947 until the late 1960s, but the Vietnam War and the women's liberation movement led her to change her priorities. Also, after being promoted in 1973 from what she called the "typical women's ghetto" of "research associate and lecturer" positions to a tenured faculty position at Harvard, she felt increased freedom to pursue new interests. 
She became known as a strong critic of sociobiology. Geneticist Richard Lewontin has said, "No one has been a more influential critic of the biological theory of women's inequality than Ruth Hubbard." In a 2006 essay entitled "Race and Genes," she wrote:
It is beyond comprehension, in this century which has witnessed holocausts of ethnic, racial, and religious extermination in many parts of our planet, perpetrated by peoples of widely different cultural and political affiliations and beliefs, that educated persons—scholars and popularizers alike—can come forward to argue, as though in complete innocence and ignorance of our recent history, that nothing could be more interesting and worthwhile than to sort out the “racial” or “ethnic” components of our thoroughly mongrelized species so as to ascertain the root identity of each and everyone of us. And where to look for that identity if not in our genes?
Commentary on gender and science 
In her essay "Science and Science Criticism," published in 2001 as a chapter of The Gender and Science Reader, Hubbard iterates that she is a scientist and states that "[n]ature is part of history and culture", but not vice versa. She goes on to say that scientists are largely unable to grasp the concept of nature being part of life--- noting how she needed several years to understand the statement. Going into her scientific history, the narrator mentions how she originally never questioned how her efforts fit into society. Narrowing her focus, she exposits that the Vietnam-era women's rights and women's liberation movements helped teach her of the roles of science in society.
She continues forth with the various means of debate for both sides. One notable instance from men is when they revive various old and unfounded biological theories on women to justify the typical subservient positions of the female gender. Hubbard even refers to the means of debate as "breathing new life" into old theories and assumptions. She further exposits the issues revolving around gender equality that were mainly brought to her attention by how she and her colleagues suddenly started getting promoted from their "ghetto" lab positions right into proper titles. She promptly stresses that "[she believes] the subject of women's biology is profoundly political", explaining away the book's title as she does so. Proceeding onward her desire to go beyond "defining [women as a whole] as victims of male power and dominance," and pushes for women everywhere to show independence and individuality while learning to accept and embrace the biology that's continuously used by men to undermine them. To follow up, she goes on to talk about women's health activists re-educating women on the functions of their body and goes on to encourage women to use the re-education to attain great power by eliminating the footholds of male misinformation and misrepresentation of their bodies.
The essay asserts that women scientists must ultimately and paradoxically turn away from the sciences to make their stand against male supremacy as opposed to the many female and feminist poets, novelists, and artists that can illustrate their points clearly and easily. She notes that politics seems to vanish within the sciences, exemplifying this point by noting social classes aren't a specific category listed under US health studies. The point she makes is that social and political realities can be blended or integrated subtly into all mediums. The subtlety of the integration ultimately creates great difficulty in discerning fact from prejudice. In addition, artists, novelists, and poets can compose their works without being victim to review under the funding agencies that makes the use of scientific fact tedious and less effective. The author leads in to surmise that the issues around women's rights must be raised and brought into public focus. After bringing up how science integrates itself into culture, she exemplifies the point by noting the prominence of biological terms in historical terminology and alluringly points out a biologist's tendency to place humanity above all other animals--- not unlike how men view women and their desire for equality. She raises the question of whether or not women can improve the sciences but makes an attempt to bring into attention her belief that women can make an impact. Hubbard closes by saying that scientists never want their work to be forgotten and lost, and that she sides with feminism for political insight and analytic testing on the scientific assumptions about women.
Partial bibliography 
- Ruth Hubbard and George Wald (1952), Cis-trans Isomers of Vitamin A and Retinene in the Rhodopsin System, The Journal of General Physiology, Vol 36, 269-315
- Ruth Hubbard, Robert I. Gregerman, and George Wald (1953), Geometrical Isomers of Retinene, The Journal of General Physiology, Vol 36, 415-429
- Ruth Hubbard and Robert C. C. St. George (1958), The Rhodopsin System of the Squid, The Journal of General Physiology 1958 January 20; 41(3): 501–528.
- Ruth Hubbard and Allen Kropf (1958), The Action of Light on Rhodopsin, Proceedings National Academy of Sciences U S A. 1958 February; 44(2): 130–139.
- Ruth Hubbard,Deric Bownds, and Tôru Yoshizawa (1965), The Chemistry of Visual Photoreception, Cold Spring Harbor Symposium on Quantitative Biology 1965. 30:301-315
- Ruth Hubbard (1988), Science, Facts and Feminism, Hypatia, v. 3, no. 1 (Spring 1988)
- R. Hubbard and R.C. Lewontin (1996), Pitfalls of Genetic Testing, New England Journal of Medicine, Volume 334:1192-1194, Number 18, 2 May, 1996
- Ruth Hubbard (2006), Race & Genes, in Is Race Real?, a web forum sponsored by the Social Science Research Council, June 7, 2006
- Ruth Hubbard (1990), The Politics of Women's Biology, Rutgers University Press. ISBN 0-8135-1490-8, ISBN 978-0-8135-1490-1
- Ruth Hubbard and Elijah Wald (1993), Exploding the Gene Myth: How Genetic Information Is Produced and Manipulated by Scientists, Physicians, Employers, Insurance Companies, Educators, and Law Enforcers, Beacon Press. ISBN 0-8070-0431-6, ISBN 978-0-8070-0431-9
- Ruth Hubbard (1995), Profitable Promises: Essays on Women, Science & Health, Common Courage Press. ISBN 1-56751-041-8, ISBN 978-1-56751-041-6
- Ruth Hubbard, Cambridge Forum Speakers 1970-1990, accessed November 29, 2009
- Holloway, M. (1995) Profile: Ruth Hubbard – Turning the Inside Out, Scientific American 272(6), 49-50.
- "Ruth Hubbard". HowStuffWorks (Discovery Communications). Retrieved January 27, 2011.
- John E. Dowling, "George Wald, 1906–1997: A Biographical Memoir" in Biographical Memoirs, Washington, D.C.: The National Academy Press (National Academy of Sciences), Volume 78, 298:317.
- "How to Think About Science: Episode 19 - Ruth Hubbard". Canadian Broadcasting Corporation via Public Radio Exchange (PRX). Retrieved January 27, 2011.
- Ruth Hubbard (1990), The Politics of Women's Biology, Rutgers University Press. ISBN 0-8135-1490-8, ISBN 978-0-8135-1490-1. pages 1-2.
- Ruth Hubbard, Harvard University Department of the History of Science, web content accessed July 27, 2011
- Ruth Hubbard (2006), Race & Genes
- Ruth Hubbard (2001). "Science and Science Criticism". In Muriel Lederman, Ingrid Bartsch. The Gender and Science Reader. Psychology Press. pp. 49–51. ISBN 9780415213585.
- Exploding the Gene Myth A Conversation with Ruth Hubbard
- Ruth Hubbard interview (multimedia stream), WGBH Science Luminaries series, 2007
- Episode 19 - Ruth Hubbard, in "How to Think About Science" series, Canadian Broadcasting Corporation