S100A11

S100 calcium binding protein A11
Rendering based on PDB 1V4Z.
Available structures PDB 1V4Z, 1V50
Identifiers
Symbols	S100A11; MLN70; S100C
External IDs	OMIM: 603114 MGI: 3645720 HomoloGene: 55916 GeneCards: S100A11 Gene
Gene Ontology Molecular function • calcium ion binding • protein binding • protein homodimerization activity • S100 beta binding • calcium-dependent protein binding Cellular component • ruffle • nucleus • cytoplasm • cytoplasm Biological process • signal transduction • negative regulation of DNA replication • negative regulation of cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6282	20195
Ensembl	ENSG00000163191	ENSMUSG00000027907
UniProt	P31949	n/a
RefSeq (mRNA)	NM_005620	NM_016740.3
RefSeq (protein)	NP_005611	NP_058020.1
Location (UCSC)	Chr 1: 152 – 152.02 Mb	Chr 3: 93.32 – 93.33 Mb
PubMed search	[1]	[2]

Protein S100-A11 is a protein that in humans is encoded by the S100A11 gene.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.

Interactions

S100A11 has been shown to interact with Nucleolin and S100B.

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. 
• Tomasetto C, Régnier C, Moog-Lutz C, et al. (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.". Genomics 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069. 
• Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097. 
• Tanaka M, Adzuma K, Iwami M, et al. (1995). "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis.". Cancer Lett. 89 (2): 195–200. doi:10.1016/0304-3835(94)03687-E. PMID 7889529. 
• Mailliard WS, Haigler HT, Schlaepfer DD (1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I.". J. Biol. Chem. 271 (2): 719–25. doi:10.1074/jbc.271.2.719. PMID 8557678. 
• Seemann J, Weber K, Gerke V (1997). "Annexin I targets S100C to early endosomes.". FEBS Lett. 413 (1): 185–90. doi:10.1016/S0014-5793(97)00911-3. PMID 9287141. 
• Inada H, Naka M, Tanaka T, et al. (1999). "Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization.". Biochem. Biophys. Res. Commun. 263 (1): 135–8. doi:10.1006/bbrc.1999.1319. PMID 10486266. 
• Réty S, Osterloh D, Arié JP, et al. (2000). "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.". Structure 8 (2): 175–84. doi:10.1016/S0969-2126(00)00093-9. PMID 10673436. 
• Sakaguchi M, Miyazaki M, Inoue Y, et al. (2000). "Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts.". J. Cell Biol. 149 (6): 1193–206. doi:10.1083/jcb.149.6.1193. PMC 2175115. PMID 10851017. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175115. 
• Deloulme JC, Assard N, Mbele GO, et al. (2001). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo.". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138. 
• Ruse M, Lambert A, Robinson N, et al. (2001). "S100A7, S100A10, and S100A11 are transglutaminase substrates.". Biochemistry 40 (10): 3167–73. doi:10.1021/bi0019747. PMID 11258932. 
• Kondo A, Sakaguchi M, Makino E, et al. (2002). "Localization of S100C immunoreactivity in various human tissues.". Acta Med. Okayama 56 (1): 31–4. PMID 11873942. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bianchi R, Giambanco I, Arcuri C, Donato R (2003). "Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments.". Microsc. Res. Tech. 60 (6): 639–51. doi:10.1002/jemt.10305. PMID 12645011. 
• Broome AM, Ryan D, Eckert RL (2003). "S100 protein subcellular localization during epidermal differentiation and psoriasis.". J. Histochem. Cytochem. 51 (5): 675–85. PMID 12704215. 
• Sakaguchi M, Miyazaki M, Takaishi M, et al. (2004). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.". J. Cell Biol. 163 (4): 825–35. doi:10.1083/jcb.200304017. PMC 2173690. PMID 14623863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173690. 
• Broome AM, Eckert RL (2004). "Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor.". J. Invest. Dermatol. 122 (1): 29–38. doi:10.1046/j.0022-202X.2003.22105.x. PMID 14962086. 
• Sakaguchi M, Miyazaki M, Sonegawa H, et al. (2004). "PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11.". J. Cell Biol. 164 (7): 979–84. doi:10.1083/jcb.200312041. PMC 2172059. PMID 15051732. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172059. 
• Mori M, Shimada H, Gunji Y, et al. (2004). "S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer.". Oncol. Rep. 11 (6): 1287–93. PMID 15138568.