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S100 calcium-binding protein A11
Protein S100A11 PDB 1V4Z.png
Rendering based on PDB 1V4Z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols S100A11 ; HEL-S-43; MLN70; S100C
External IDs OMIM603114 MGI3645720 HomoloGene55916 GeneCards: S100A11 Gene
RNA expression pattern
PBB GE S100A11 200660 at tn.png
More reference expression data
Species Human Mouse
Entrez 6282 277089
Ensembl ENSG00000163191 ENSMUSG00000027907
UniProt P31949 P50543
RefSeq (mRNA) NM_005620 NM_016740
RefSeq (protein) NP_005611 NP_058020
Location (UCSC) Chr 1:
152 – 152.02 Mb
Chr 3:
93.52 – 93.53 Mb
PubMed search [1] [2]

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene.[1][2]


The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.[2]


S100A11 has been shown to interact with Nucleolin[3] and S100B.[4]


  1. ^ Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (March 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590. 
  2. ^ a b "Entrez Gene: S100A11 S100 calcium binding protein A11". 
  3. ^ Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N et al. (November 2003). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes". J. Cell Biol. 163 (4): 825–35. doi:10.1083/jcb.200304017. PMC 2173690. PMID 14623863. 
  4. ^ Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (November 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138. 

Further reading[edit]