S100A11

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S100 calcium binding protein A11
Protein S100A11 PDB 1V4Z.png
Rendering based on PDB 1V4Z.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols S100A11 ; MLN70; S100C
External IDs OMIM603114 MGI3645720 HomoloGene55916 GeneCards: S100A11 Gene
RNA expression pattern
PBB GE S100A11 200660 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6282 20195
Ensembl ENSG00000163191 ENSMUSG00000027907
UniProt P31949 P50543
RefSeq (mRNA) NM_005620 NM_016740
RefSeq (protein) NP_005611 NP_058020
Location (UCSC) Chr 1:
152 – 152.02 Mb
Chr 3:
93.52 – 93.53 Mb
PubMed search [1] [2]

Protein S100-A11 is a protein that in humans is encoded by the S100A11 gene.[1][2]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.[2]

Interactions[edit]

S100A11 has been shown to interact with Nucleolin[3] and S100B.[4]

References[edit]

  1. ^ Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (March 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590. 
  2. ^ a b "Entrez Gene: S100A11 S100 calcium binding protein A11". 
  3. ^ Sakaguchi, Masakiyo; Miyazaki Masahiro, Takaishi Mikiro, Sakaguchi Yoshihiko, Makino Eiichi, Kataoka Noriyuki, Yamada Hidenori, Namba Masayoshi, Huh Nam-ho (November 2003). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes". J. Cell Biol. (United States) 163 (4): 825–35. doi:10.1083/jcb.200304017. ISSN 0021-9525. PMC 2173690. PMID 14623863. 
  4. ^ Deloulme, J C; Assard N, Mbele G O, Mangin C, Kuwano R, Baudier J (November 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. (UNITED STATES) 275 (45): 35302–10. doi:10.1074/jbc.M003943200. ISSN 0021-9258. PMID 10913138. 

Further reading[edit]