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S100 calcium-binding protein A12
Protein S100A12 PDB 1e8a.png
PDB rendering based on 1e8a.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols S100A12 ; CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6
External IDs OMIM603112 HomoloGene48361 GeneCards: S100A12 Gene
RNA expression pattern
PBB GE S100A12 205863 at tn.png
More reference expression data
Species Human Mouse
Entrez 6283 n/a
Ensembl ENSG00000163221 n/a
UniProt P80511 n/a
RefSeq (mRNA) NM_005621 n/a
RefSeq (protein) NP_005612 n/a
Location (UCSC) Chr 1:
153.35 – 153.35 Mb
PubMed search [1] n/a

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene.[1][2] It is also known as calgranulin C.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.[2]


  1. ^ Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (Mar 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590. 
  2. ^ a b "Entrez Gene: S100A12 S100 calcium binding protein A12". 

Further reading[edit]