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S100 calcium-binding protein A13
Protein S100A13 PDB 1yur.png
PDB rendering based on 1yur.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol S100A13
External IDs OMIM601989 MGI109581 HomoloGene7523 GeneCards: S100A13 Gene
RNA expression pattern
PBB GE S100A13 202598 at tn.png
More reference expression data
Species Human Mouse
Entrez 6284 20196
Ensembl ENSG00000189171 ENSMUSG00000042312
UniProt Q99584 Q545H7
RefSeq (mRNA) NM_001024210 NM_009113
RefSeq (protein) NP_001019381 NP_033139
Location (UCSC) Chr 1:
153.59 – 153.61 Mb
Chr 3:
90.51 – 90.52 Mb
PubMed search [1] [2]

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.[1][2]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]


S100A13 has been shown to interact with SYT1[3][4] and FGF1.[3][4]


  1. ^ Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (March 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590. 
  2. ^ a b "Entrez Gene: S100A13 S100 calcium binding protein A13". 
  3. ^ a b Mouta Carreira, C; LaVallee T M; Tarantini F; Jackson A; Lathrop J T; Hampton B; Burgess W H; Maciag T (August 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". J. Biol. Chem. (UNITED STATES) 273 (35): 22224–31. doi:10.1074/jbc.273.35.22224. ISSN 0021-9258. PMID 9712836. 
  4. ^ a b Landriscina, M; Bagalá C; Mandinova A; Soldi R; Micucci I; Bellum S; Prudovsky I; Maciag T (July 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". J. Biol. Chem. (United States) 276 (27): 25549–57. doi:10.1074/jbc.M102925200. ISSN 0021-9258. PMID 11432880. 

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