The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
^Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (March 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID8985590.
^ abMouta Carreira, C; LaVallee T M, Tarantini F, Jackson A, Lathrop J T, Hampton B, Burgess W H, Maciag T (August 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". J. Biol. Chem. (UNITED STATES) 273 (35): 22224–31. doi:10.1074/jbc.273.35.22224. ISSN0021-9258. PMID9712836.Cite uses deprecated parameters (help)
^ abLandriscina, M; Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T (July 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". J. Biol. Chem. (United States) 276 (27): 25549–57. doi:10.1074/jbc.M102925200. ISSN0021-9258. PMID11432880.Cite uses deprecated parameters (help)
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Hsieh HL, Schäfer BW, Cox JA, Heizmann CW (2003). "S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells.". J. Cell. Sci.115 (Pt 15): 3149–58. PMID12118070.
Chan WY, Xia CL, Dong DC, et al. (2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex.". Microsc. Res. Tech.60 (6): 600–13. doi:10.1002/jemt.10302. PMID12645008.
Mandinova A, Soldi R, Graziani I, et al. (2004). "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.". J. Cell. Sci.116 (Pt 13): 2687–96. doi:10.1242/jcs.00471. PMID12746488.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Hsieh HL, Schäfer BW, Weigle B, Heizmann CW (2004). "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells.". Biochem. Biophys. Res. Commun.316 (3): 949–59. doi:10.1016/j.bbrc.2004.02.135. PMID15033494.