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S100 calcium binding protein A4
Protein S100A4 PDB 1m31.png
PDB rendering based on 1m31.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols S100A4 ; 18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98
External IDs OMIM114210 MGI1330282 HomoloGene7924 GeneCards: S100A4 Gene
RNA expression pattern
PBB GE S100A4 203186 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6275 20198
Ensembl ENSG00000196154 ENSMUSG00000001020
UniProt P26447 P07091
RefSeq (mRNA) NM_002961 NM_011311
RefSeq (protein) NP_002952 NP_035441
Location (UCSC) Chr 1:
153.52 – 153.52 Mb
Chr 3:
90.6 – 90.61 Mb
PubMed search [1] [2]

Protein S100-A4 is a protein that in humans is encoded by the S100A4 gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]


S100A4 has been shown to interact with S100 calcium binding protein A1.[3][4]


  1. ^ Stoler A, Bouck N (March 1985). "Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation". Proc Natl Acad Sci U S A 82 (2): 570–4. doi:10.1073/pnas.82.2.570. PMC 397082. PMID 3155863. 
  2. ^ "Entrez Gene: S100A4 S100 calcium binding protein A4". 
  3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Wang, G; Rudland P S, White M R, Barraclough R (April 2000). "Interaction in vivo and in vitro of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1". J. Biol. Chem. (UNITED STATES) 275 (15): 11141–6. doi:10.1074/jbc.275.15.11141. ISSN 0021-9258. PMID 10753920. 

Further reading[edit]