S100A5

S100 calcium binding protein A5
Rendering based on PDB 2KAX.
Available structures PDB 2KAX, 2KAY
Identifiers
Symbols	S100A5; S100D
External IDs	OMIM: 176991 MGI: 1338915 HomoloGene: 2224 GeneCards: S100A5 Gene
Gene Ontology Molecular function • copper ion binding • calcium ion binding • zinc ion binding • protein homodimerization activity Cellular component • nucleus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6276	20199
Ensembl	ENSG00000196420	ENSMUSG00000001023
UniProt	P33763	P63084
RefSeq (mRNA)	NM_002962.1	NM_011312.2
RefSeq (protein)	NP_002953.2	NP_035442.1
Location (UCSC)	Chr 1: 153.51 – 153.51 Mb	Chr 3: 90.41 – 90.42 Mb
PubMed search	[1]	[2]

Protein S100-A5 is a protein that in humans is encoded by the S100A5 gene.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca²⁺ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn²⁺ and Cu²⁺, and Cu²⁺ strongly which impairs the binding of Ca²⁺. This protein is expressed in very restricted regions of the adult brain.

Further reading

• Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470. 
• Schäfer BW, Wicki R, Engelkamp D et al (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097. 
• Ridinger K, Ilg EC, Niggli FK et al (1999). "Clustered organization of S100 genes in human and mouse". Biochim. Biophys. Acta 1448 (2): 254–63. PMID 9920416. 
• Schäfer BW, Fritschy JM, Murmann P et al (2000). "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily". J. Biol. Chem. 275 (39): 30623–30. doi:10.1074/jbc.M002260200. PMID 10882717. 
• Bronckart Y, Decaestecker C, Nagy N et al (2002). "Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins". Histol. Histopathol. 16 (3): 707–12. PMID 11510959. 
• Teratani T, Watanabe T, Yamahara K et al (2002). "Restricted expression of calcium-binding protein S100A5 in human kidney". Biochem. Biophys. Res. Commun. 291 (3): 623–7. doi:10.1006/bbrc.2002.6494. PMID 11855835. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chan WY, Xia CL, Dong DC et al (2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microsc. Res. Tech. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008. 
• Gregory SG, Barlow KF, McLay KE et al (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.