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S100 calcium binding protein P
Protein S100P PDB 1j55.png
PDB rendering based on 1j55.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols S100P ; MIG9
External IDs OMIM600614 HomoloGene81743 GeneCards: S100P Gene
RNA expression pattern
PBB GE S100P 204351 at tn.png
More reference expression data
Species Human Mouse
Entrez 6286 n/a
Ensembl ENSG00000163993 n/a
UniProt P25815 n/a
RefSeq (mRNA) NM_005980 n/a
RefSeq (protein) NP_005971 n/a
Location (UCSC) Chr 4:
6.69 – 6.7 Mb
PubMed search [1] n/a

Protein S100-P is a protein that in humans is encoded by the S100P gene.[1][2][3]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.[3]


S100P has been shown to interact with EZR.[4]


  1. ^ Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667. 
  2. ^ Schafer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Jun 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097. 
  3. ^ a b "Entrez Gene: S100P S100 calcium binding protein P". 
  4. ^ Koltzscher, Max; Neumann Claudia, König Simone, Gerke Volker (Jun 2003). "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P". Mol. Biol. Cell (United States) 14 (6): 2372–84. doi:10.1091/mbc.E02-09-0553. ISSN 1059-1524. PMC 194886. PMID 12808036. 

Further reading[edit]