Serum amyloid A1

Serum amyloid A1
Identifiers
Symbols	SAA1; PIG4; SAA; SAA2; TP53I4
External IDs	OMIM: 104750 MGI: 98221 HomoloGene: 81819 GeneCards: SAA1 Gene
Gene Ontology Molecular function • G-protein coupled receptor binding Cellular component • extracellular region • extracellular region • high-density lipoprotein particle Biological process • acute-phase response • elevation of cytosolic calcium ion concentration • elevation of cytosolic calcium ion concentration • platelet activation • neutrophil chemotaxis • innate immune response • positive regulation of cell adhesion • positive regulation of cell adhesion • macrophage chemotaxis • lymphocyte chemotaxis • regulation of protein secretion • positive regulation of cytokine secretion • positive regulation of interleukin-1 secretion • negative regulation of inflammatory response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6288	20210
Ensembl	ENSG00000173432	ENSMUSG00000040026
UniProt	P02735	P04918
RefSeq (mRNA)	NM_000331.4	NM_011315.3
RefSeq (protein)	NP_000322.2	NP_035445.1
Location (UCSC)	Chr 11: 18.29 – 18.29 Mb	Chr 7: 53.97 – 53.97 Mb
PubMed search	[1]	[2]

Serum amyloid A protein is a protein that in humans is encoded by the SAA1 gene.

Further reading

• Kisilevsky R, Tam SP (2002). "Acute phase serum amyloid A, cholesterol metabolism, and cardiovascular disease.". Pediatric pathology & molecular medicine 21 (3): 291–305. doi:10.1080/02770930290056523. PMID 12056504. 
• Sletten K, Husby G, Natvig JB (1976). "The complete amino acid sequence of an amyloid fibril protein AA1 of unusual size (64 residues).". Biochem. Biophys. Res. Commun. 69 (1): 19–25. doi:10.1016/S0006-291X(76)80266-5. PMID 1259755. 
• Beach CM, De Beer MC, Sipe JD, et al. (1992). "Human serum amyloid A protein. Complete amino acid sequence of a new variant.". Biochem. J. 282 (2): 615–20. PMC 1130826. PMID 1546977. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1130826. 
• Betts JC, Edbrooke MR, Thakker RV, Woo P (1991). "The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells.". Scand. J. Immunol. 34 (4): 471–82. doi:10.1111/j.1365-3083.1991.tb01570.x. PMID 1656519. 
• Zimlichman S, Danon A, Nathan I, et al. (1990). "Serum amyloid A, an acute phase protein, inhibits platelet activation.". J. Lab. Clin. Med. 116 (2): 180–6. PMID 1697614. 
• Steinkasserer A, Weiss EH, Schwaeble W, Linke RP (1990). "Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis.". Biochem. J. 268 (1): 187–93. PMC 1131410. PMID 1971508. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1131410. 
• Sack GH, Talbot CC (1991). "Highly polymorphic domains of the human serum amyloid A (SAA) gene GSAA1.". Scand. J. Immunol. 33 (4): 485–8. doi:10.1111/j.1365-3083.1991.tb01797.x. PMID 2017667. 
• Woo P, Sipe J, Dinarello CA, Colten HR (1987). "Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells.". J. Biol. Chem. 262 (32): 15790–5. PMID 2890635. 
• Kluve-Beckerman B, Dwulet FE, Benson MD (1988). "Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person.". J. Clin. Invest. 82 (5): 1670–5. doi:10.1172/JCI113779. PMC 442736. PMID 3183061. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442736. 
• Prelli F, Pras M, Frangione B (1988). "Degradation and deposition of amyloid AA fibrils are tissue specific.". Biochemistry 26 (25): 8251–6. doi:10.1021/bi00399a035. PMID 3442653. 
• Kluve-Beckerman B, Long GL, Benson MD (1987). "DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA).". Biochem. Genet. 24 (11-12): 795–803. doi:10.1007/BF00554519. PMID 3800865. 
• Sipe JD, Colten HR, Goldberger G, et al. (1985). "Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA.". Biochemistry 24 (12): 2931–6. doi:10.1021/bi00333a018. PMID 3839415. 
• Sletten K, Husby G (1974). "The complete amino-acid sequence of non-immunoglobulin amyloid fibril protein AS in rheumatoid arthritis.". Eur. J. Biochem. 41 (1): 117–25. doi:10.1111/j.1432-1033.1974.tb03251.x. PMID 4816450. 
• Ein D, Kimura S, Terry WD, et al. (1972). "Amino acid sequence of an amyloid fibril protein of unknown origin.". J. Biol. Chem. 247 (17): 5653–5. PMID 5055786. 
• Levin M, Franklin EC, Frangione B, Pras M (1972). "The amino acid sequence of a major nonimmunoglobulin component of some amyloid fibrils.". J. Clin. Invest. 51 (10): 2773–6. doi:10.1172/JCI107098. PMC 332979. PMID 5056669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=332979. 
• Møyner K, Sletten K, Husby G, Natvig JB (1980). "An unusually large (83 amino acid residues) amyloid fibril protein AA from a patient with Waldenström's macroglobulinaemia and amyloidosis.". Scand. J. Immunol. 11 (5): 549–54. doi:10.1111/j.1365-3083.1980.tb00023.x. PMID 6155694. 
• Parmelee DC, Titani K, Ericsson LH, et al. (1982). "Amino acid sequence of amyloid-related apoprotein (apoSAA1) from human high-density lipoprotein.". Biochemistry 21 (14): 3298–303. doi:10.1021/bi00257a008. PMID 7115671. 
• Badolato R, Wang JM, Murphy WJ, et al. (1994). "Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes.". J. Exp. Med. 180 (1): 203–9. doi:10.1084/jem.180.1.203. PMC 2191543. PMID 7516407. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191543. 
• Badolato R, Johnston JA, Wang JM, et al. (1995). "Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.". J. Immunol. 155 (8): 4004–10. PMID 7561109.