SAE1

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SUMO1 activating enzyme subunit 1
Protein SAE1 PDB 1y8q.png
PDB rendering based on 1y8q.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SAE1 ; AOS1; HSPC140; SUA1; UBLE1A
External IDs OMIM613294 MGI1929264 HomoloGene4019 ChEMBL: 1615388 GeneCards: SAE1 Gene
RNA expression pattern
PBB GE SAE1 217946 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10055 56459
Ensembl ENSG00000142230 ENSMUSG00000052833
UniProt Q9UBE0 Q9R1T2
RefSeq (mRNA) NM_001145713 NM_019748
RefSeq (protein) NP_001139185 NP_062722
Location (UCSC) Chr 19:
47.62 – 47.71 Mb
Chr 7:
16.33 – 16.39 Mb
PubMed search [1] [2]

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.[1][2][3][4]


Interactions[edit]

SAE1 has been shown to interact with SAE2.[1][3][5][6]

References[edit]

  1. ^ a b Desterro JM, Rodriguez MS, Kemp GD, Hay RT (May 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J Biol Chem 274 (15): 10618–24. doi:10.1074/jbc.274.15.10618. PMID 10187858. 
  2. ^ Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H (Mar 1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem Biophys Res Commun 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803. 
  3. ^ a b Gong L, Li B, Millas S, Yeh ET (Jun 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett 448 (1): 185–9. doi:10.1016/S0014-5793(99)00367-1. PMID 10217437. 
  4. ^ "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1". 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]

External links[edit]