SAFB

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Scaffold attachment factor B
Identifiers
Symbols SAFB ; HAP; HET; SAF-B1; SAFB1
External IDs OMIM602895 MGI2146974 HomoloGene2229 GeneCards: SAFB Gene
RNA expression pattern
PBB GE SAFB 201748 s at tn.png
PBB GE SAFB 201747 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6294 224903
Ensembl ENSG00000160633 ENSMUSG00000071054
UniProt Q15424 D3YXK2
RefSeq (mRNA) NM_001201338 NM_001163300
RefSeq (protein) NP_001188267 NP_001156772
Location (UCSC) Chr 19:
5.62 – 5.67 Mb
Chr 17:
56.58 – 56.61 Mb
PubMed search [1] [2]

Scaffold attachment factor B, also known as SAFB, is a gene with homologs that have been studied in humans and mice.[1]

This gene encodes a DNA-binding protein that has specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there are conflicting views as to whether this protein is a component of chromatin, the nuclear matrix, or both. Scaffold attachment factors are a subset of nuclear matrix proteins (NMP) with enriched binding to AT-rich S/MAR sequences. The SAF-B protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.[1]

Interactions[edit]

SAFB has been shown to interact with Estrogen receptor alpha,[2][3] TAF15,[2] SAFB2[4] and HNRPD.[5]

References[edit]

  1. ^ a b "Entrez Gene: SAFB scaffold attachment factor B". 
  2. ^ a b Townson, Steven M; Kang Kaiyan; Lee Adrian V; Oesterreich Steffi (June 2004). "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain". J. Biol. Chem. (United States) 279 (25): 26074–81. doi:10.1074/jbc.M313726200. ISSN 0021-9258. PMID 15066997. 
  3. ^ Oesterreich, S; Zhang Q; Hopp T; Fuqua S A; Michaelis M; Zhao H H; Davie J R; Osborne C K; Lee A V (March 2000). "Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation". Mol. Endocrinol. (UNITED STATES) 14 (3): 369–81. doi:10.1210/me.14.3.369. ISSN 0888-8809. PMID 10707955. 
  4. ^ Townson, Steven M; Dobrzycka Klaudia M; Lee Adrian V; Air Mamie; Deng Wanleng; Kang Kaiyan; Jiang Shiming; Kioka Noriyuki; Michaelis Kai; Oesterreich Steffi (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. (United States) 278 (22): 20059–68. doi:10.1074/jbc.M212988200. ISSN 0021-9258. PMID 12660241. 
  5. ^ Arao, Y; Kuriyama R; Kayama F; Kato S (August 2000). "A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D". Arch. Biochem. Biophys. (UNITED STATES) 380 (2): 228–36. doi:10.1006/abbi.2000.1938. ISSN 0003-9861. PMID 10933876. 

Further reading[edit]