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SAIC may refer to:
- Leidos, an American government contractor, known as Science Applications International Corporation (SAIC) from 1969 to 2013
- Science Applications International Corporation, an American government contractor created in 2013 during a split of Leidos
- SAIC Motor, a China-based automaker formerly named Shanghai Automotive Industry Corporation
- School of the Art Institute of Chicago, one of America's largest accredited independent schools of art and design, located in the Loop in Chicago, Illinois
- Special Agent in Charge, a detective or investigator for a state, county, municipal, federal or tribal government
- South African Indian Congress, an organization founded in 1924 in Natal (now KwaZulu-Natal), South Africa
- Single antenna interference cancellation, a promising technology to boost the capacity of GSM networks without any needed change in the network
- State Administration for Industry and Commerce, the authority in the People's Republic of China responsible for advancing legislation concerning the administration of industry and commerce
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