SAMPLE history is an mnemonicacronym to remember key questions for a person's medical assessment. The SAMPLE history is sometimes used in conjunction with vital signs and OPQRST. The questions are most commonly used in the field of emergency medicine by first responders. It is used for alert people, but often much of this information can also be obtained from the family or friend of an unresponsive person. A derivative of SAMPLE history is AMPLE history which places a greater emphasis on a person's medical history.