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Sin3A-associated protein, 130kDa
Symbols SAP130 ; FLJ12761
External IDs OMIM609697 MGI1919782 HomoloGene11577 ChEMBL: 1229012 GeneCards: SAP130 Gene
EC number
RNA expression pattern
PBB GE SAP130 220367 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79595 269003
Ensembl ENSG00000136715 ENSMUSG00000024260
UniProt Q9H0E3 Q8BIH0
RefSeq (mRNA) NM_001145928 NM_172965
RefSeq (protein) NP_001139400 NP_766553
Location (UCSC) Chr 2:
127.94 – 128.03 Mb
Chr 18:
31.63 – 31.72 Mb
PubMed search [1] [2]

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.[1][2][3]

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM][3]


SAP130 has been shown to interact with CSN1S1,[4] SIN3A,[2] Myc,[5] Von Hippel-Lindau tumor suppressor[4] and CUL2.[4]


  1. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. 
  2. ^ a b Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol Cell Biol 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404. 
  3. ^ a b "Entrez Gene: SAP130 Sin3A-associated protein, 130kDa". 
  4. ^ a b c Menon, Suchithra; Tsuge Tomohiko; Dohmae Naoshi; Takio Koji; Wei Ning (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. (England) 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839. 
  5. ^ Liu, Xiaohui; Tesfai Jerusalem; Evrard Yvonne A; Dent Sharon Y R; Martinez Ernest (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". J. Biol. Chem. (United States) 278 (22): 20405–12. doi:10.1074/jbc.M211795200. ISSN 0021-9258. PMC 4031917. PMID 12660246. 

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