SART3

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Squamous cell carcinoma antigen recognized by T cells 3
Protein SART3 PDB 2do4.png
PDB rendering based on 2do4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SART3 ; DSAP1; P100; RP11-13G14; TIP110; p110; p110(nrb)
External IDs OMIM611684 MGI1858230 HomoloGene40977 GeneCards: SART3 Gene
RNA expression pattern
PBB GE SART3 209127 s at tn.png
PBB GE SART3 209128 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9733 53890
Ensembl ENSG00000075856 ENSMUSG00000018974
UniProt Q15020 Q9JLI8
RefSeq (mRNA) NM_014706 NM_016926
RefSeq (protein) NP_055521 NP_058622
Location (UCSC) Chr 12:
108.92 – 108.96 Mb
Chr 5:
113.74 – 113.77 Mb
PubMed search [1] [2]

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.[1][1][2][2][3]

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.[3]

Interactions[edit]

SART3 has been shown to interact with RNPS1[4] and Androgen receptor.[5]

References[edit]

  1. ^ a b Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (March 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280. 
  2. ^ a b Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K (April 2000). "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen". Jpn J Cancer Res 91 (2): 239–47. doi:10.1111/j.1349-7006.2000.tb00937.x. PMID 10761712. 
  3. ^ a b "Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3". 
  4. ^ Harada, K; Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". Int. J. Cancer (United States) 93 (5): 623–8. doi:10.1002/ijc.1391. ISSN 0020-7136. PMID 11477570. 
  5. ^ Liu, Ying; Kim Byung Oh, Kao Chinghai, Jung Chaeyong, Dalton James T, He Johnny J (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". J. Biol. Chem. (United States) 279 (21): 21766–73. doi:10.1074/jbc.M314321200. ISSN 0021-9258. PMID 15031286. 

Further reading[edit]