SATB1

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SATB homeobox 1
Protein SATB1 PDB 1yse.png
PDB rendering based on 1yse.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol SATB1
External IDs OMIM602075 MGI105084 HomoloGene2232 GeneCards: SATB1 Gene
RNA expression pattern
PBB GE SATB1 203408 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6304 20230
Ensembl ENSG00000182568 ENSMUSG00000023927
UniProt Q01826 Q60611
RefSeq (mRNA) NM_001131010 NM_001163630
RefSeq (protein) NP_001124482 NP_001157102
Location (UCSC) Chr 3:
18.39 – 18.49 Mb
Chr 17:
51.74 – 51.83 Mb
PubMed search [1] [2]

SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene.[1]

Function[edit]

SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation.[2] Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli.[3] At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1 has also been shown to induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.

Interactions[edit]

SATB1 has been shown to interact with HDAC1,[4] SMARCA5,[4] MTA2,[4] CHD4,[4] CUTL1,[5] POLR2J[6] and BAZ1A.[4]

References[edit]

  1. ^ "Entrez Gene: SATB1 SATB homeobox 1". 
  2. ^ Pavan Kumar P, Purbey PK, Sinha CK, Notani D, Limaye A, Jayani RS, Galande S (April 2006). "Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo". Mol. Cell 22 (2): 231–43. doi:10.1016/j.molcel.2006.03.010. PMID 16630892. 
  3. ^ Galande S, Purbey PK, Notani D, Kumar PP (October 2007). "The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1". Curr. Opin. Genet. Dev. 17 (5): 408–14. doi:10.1016/j.gde.2007.08.003. PMID 17913490. 
  4. ^ a b c d e Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi (October 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature (England) 419 (6907): 641–5. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985. 
  5. ^ Liu, J; Barnett A; Neufeld E J; Dudley J P (July 1999). "Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation". Mol. Cell. Biol. (UNITED STATES) 19 (7): 4918–26. ISSN 0270-7306. PMC 84297. PMID 10373541. 
  6. ^ Durrin, Linda K; Krontiris Theodore G (June 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics (United States) 79 (6): 809–17. doi:10.1006/geno.2002.6772. ISSN 0888-7543. PMID 12036295. 

Further reading[edit]