SB-204,070

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SB-204,070
SB-204070 structure.png
Systematic (IUPAC) name
(1-butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate
Clinical data
Legal status ?
Identifiers
CAS number 148688-01-1
ATC code ?
PubChem CID 121881
ChEMBL CHEMBL68131
Chemical data
Formula C19H27ClN2O4 
Mol. mass 382.881 g/mol

SB-204,070 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.[1][2][3][4][5]

References[edit]

  1. ^ Mialet J, Berque-Bestel I, Sicsic S, Langlois M, Fischmeister R, Lezoualc'h F (October 2000). "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology 131 (4): 827–35. doi:10.1038/sj.bjp.0703641. PMC 1572397. PMID 11030734. 
  2. ^ Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M (January 2002). "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology 61 (1): 85–96. doi:10.1124/mol.61.1.85. PMID 11752209. 
  3. ^ Takahashi H, Takada Y, Urano T, Takada A (2002). "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus 12 (3): 304–10. doi:10.1002/hipo.10012. PMID 12099482. 
  4. ^ Sakurai-Yamashita Y, Yamashita K, Niwa M, Taniyama K (May 2003). "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research 973 (1): 92–8. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957. 
  5. ^ Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H (December 2006). "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 20 (14): 2486–95. doi:10.1096/fj.06-6391com. PMID 17142798.