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SET binding factor 1
Protein SBF1 PDB 1v5u.png
PDB rendering based on 1v5u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SBF1 ; CMT4B3; DENND7A; MTMR5
External IDs OMIM603560 MGI1925230 HomoloGene84710 GeneCards: SBF1 Gene
RNA expression pattern
PBB GE SBF1 212389 at tn.png
PBB GE SBF1 212393 at tn.png
PBB GE SBF1 39835 at tn.png
More reference expression data
Species Human Mouse
Entrez 6305 77980
Ensembl ENSG00000100241 ENSMUSG00000036529
UniProt O95248 Q6ZPE2
RefSeq (mRNA) NM_002972 NM_001081030
RefSeq (protein) NP_002963 NP_001074499
Location (UCSC) Chr 22:
50.88 – 50.91 Mb
Chr 15:
89.29 – 89.32 Mb
PubMed search [1] [2]

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.[1][2][3]


SBF1 has been shown to interact with MTMR2[4] and SUV39H1.[5]


  1. ^ Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat Genet 18 (4): 331–7. doi:10.1038/ng0498-331. PMID 9537414. 
  2. ^ Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum Mol Genet 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772. 
  3. ^ "Entrez Gene: SBF1 SET binding factor 1". 
  4. ^ Kim, Soo-A; Vacratsis Panayiotis O; Firestein Ron; Cleary Michael L; Dixon Jack E (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (8): 4492–7. doi:10.1073/pnas.0431052100. ISSN 0027-8424. PMC 153583. PMID 12668758. 
  5. ^ Firestein, R; Cui X; Huie P; Cleary M L (July 2000). "Set Domain-Dependent Regulation of Transcriptional Silencing and Growth Control by SUV39H1, a Mammalian Ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. ISSN 0270-7306. PMC 85941. PMID 10848615. 

Further reading[edit]