SCAND1

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SCAND1
Identifiers
AliasesSCAND1, RAZ1, SDP1, SCAN domain containing 1
External IDsOMIM: 610416 MGI: 1343132 HomoloGene: 10642 GeneCards: SCAND1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033630
NM_016558
NM_001385710

NM_020255

RefSeq (protein)

NP_057642
NP_361012

NP_064651

Location (UCSC)Chr 20: 35.95 – 35.96 MbChr 2: 156.15 – 156.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.[5][6][7][8]

Function[edit]

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.[8]

Interactions[edit]

SCAND1 has been shown to interact with MZF1.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171222 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046229 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry. 275 (17): 12857–67. doi:10.1074/jbc.275.17.12857. PMID 10777584.
  6. ^ Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
  7. ^ Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
  8. ^ a b "Entrez Gene: SCAND1 SCAN domain containing 1".

Further reading[edit]