SCARB1

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Scavenger receptor class B, member 1
Identifiers
Symbols SCARB1 ; CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1
External IDs OMIM601040 MGI893578 HomoloGene21132 GeneCards: SCARB1 Gene
RNA expression pattern
PBB GE SCARB1 201819 at tn.png
PBB GE SCARB1 215834 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 949 20778
Ensembl ENSG00000073060 ENSMUSG00000037936
UniProt Q8WTV0 Q61009
RefSeq (mRNA) NM_001082959 NM_001205082
RefSeq (protein) NP_001076428 NP_001192011
Location (UCSC) Chr 12:
124.78 – 124.88 Mb
Chr 5:
125.28 – 125.34 Mb
PubMed search [1] [2]

Scavenger receptor class B member 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene.[1] SR-BI functions as a receptor for high-density lipoprotein.[2]

Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. It is best known for its role in facilitating the uptake of cholesteryl esters from high-density lipoproteins in the liver. This process drives the movement of cholesterol from peripheral tissues towards the liver for excretion. This movement of cholesterol is known as reverse cholesterol transport and is a protective mechanism against the development of atherosclerosis, which is the principal cause of heart disease and stroke.

SR-BI has also been identified in the livers of non-mammalian species (turtle, goldfish, shark, chicken, frog, and skate), suggesting it emerged early in vertebrate evolutionary history. The turtle also seems to upregulate SB-RI during egg development, indicating that cholesterol efflux may be at peak levels during developmental stages.[3]

In melanocytic cells SCARB1 gene expression may be regulated by the MITF.[4]

SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus in liver cells.[5]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References[edit]

  1. ^ "Entrez Gene: SCARB1 Scavenger receptor class B, member 1". 
  2. ^ Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M (January 1996). "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor". Science 271 (5248): 518–20. doi:10.1126/science.271.5248.518. PMID 8560269. 
  3. ^ Duggan AE, Marie RS, Callard IP (April 2002). "Expression of SR-BI (Scavenger Receptor Class B Type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates". J. Exp. Zool. 292 (5): 430–4. doi:10.1002/jez.10067. PMID 11857477. 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Kapadia SB, Barth H, Baumert T, McKeating JA, Chisari FV (January 2007). "Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I". J. Virol. 81 (1): 374–83. doi:10.1128/JVI.01134-06. PMC 1797271. PMID 17050612. 

Further reading[edit]