SCG5

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Secretogranin V (7B2 protein)
Identifiers
Symbols SCG5 ; 7B2; P7B2; SGNE1; SgV
External IDs OMIM173120 MGI98289 HomoloGene37722 GeneCards: SCG5 Gene
RNA expression pattern
PBB GE SCG5 203889 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6447 20394
Ensembl ENSG00000166922 ENSMUSG00000023236
UniProt P05408 P12961
RefSeq (mRNA) NM_001144757 NM_009162.3
RefSeq (protein) NP_001138229 NP_033188.3
Location (UCSC) Chr 15:
32.93 – 32.99 Mb
Chr 2:
113.62 – 113.67 Mb
PubMed search [1] [2]

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[1][2][3] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein and is required for the production of an active PC2 enzyme.[4][5] It is an intrinsically disordered protein that may also function as a chaperone for other proteins in addition to proPC2.

References[edit]

  1. ^ Lloyd RV, Jin L (May 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254. 
  2. ^ Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671. 
  3. ^ Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Lett. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253. 
  4. ^ "Entrez Gene: SCG5 secretogranin V (7B2 protein)". 
  5. ^ Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". Biochem. J. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082. 

Further reading[edit]