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Secretogranin V (7B2 protein)
Symbols SCG5 ; 7B2; P7B2; SGNE1; SgV
External IDs OMIM173120 MGI98289 HomoloGene37722 GeneCards: SCG5 Gene
RNA expression pattern
PBB GE SCG5 203889 at tn.png
More reference expression data
Species Human Mouse
Entrez 6447 20394
Ensembl ENSG00000166922 ENSMUSG00000023236
UniProt P05408 P12961
RefSeq (mRNA) NM_001144757 NM_009162
RefSeq (protein) NP_001138229 NP_033188
Location (UCSC) Chr 15:
32.93 – 32.99 Mb
Chr 2:
113.78 – 113.83 Mb
PubMed search [1] [2]

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[1][2][3] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein and is required for the production of an active PC2 enzyme.[4][5] It is an intrinsically disordered protein that may also function as a chaperone for other proteins in addition to proPC2.


  1. ^ Lloyd RV, Jin L (May 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254. 
  2. ^ Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671. 
  3. ^ Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Lett. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253. 
  4. ^ "Entrez Gene: SCG5 secretogranin V (7B2 protein)". 
  5. ^ Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". Biochem. J. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082. 

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