Mammaglobin-A

Secretoglobin, family 2A, member 2
Identifiers
Symbols	SCGB2A2; MGB1; MGC71974; UGB2
External IDs	OMIM: 605562 HomoloGene: 105651 GeneCards: SCGB2A2 Gene
Gene Ontology Molecular function • molecular_function • binding • steroid binding Cellular component • cellular_component • extracellular region Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4250	n/a
Ensembl	ENSG00000110484	n/a
UniProt	Q13296	n/a
RefSeq (mRNA)	NM_002411	n/a
RefSeq (protein)	NP_002402	n/a
Location (UCSC)	Chr 11: 62.04 – 62.04 Mb	n/a
PubMed search	[1]	n/a

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.

Function

SCGB2A2 is member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seems to be involved in cell signalling, immune response, chemotaxis, and could also serve as transporters for steroid hormones in humans.

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.

Further reading

• Wilson PC, de Bouteiller O, Liu YJ, et al. (1998). "Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.". J. Exp. Med. 187 (1): 59–70. doi:10.1084/jem.187.1.59. PMC 2199186. PMID 9419211. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199186. 
• Fischer M, Küppers R (1998). "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.". Eur. J. Immunol. 28 (9): 2971–7. doi:10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3. PMID 9754584. 
• Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.". Biochemistry 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. 
• Cerveira N, Torres L, Rocha P, et al. (2004). "Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients.". Int. J. Cancer 108 (4): 592–5. doi:10.1002/ijc.11609. PMID 14696125. 
• Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.". Am. J. Clin. Pathol. 121 (5): 637–43. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203. 
• Ferrucci PF, Rabascio C, Mazzetta C, et al. (2005). "Mammaglobin expression in leukapheresis products is a predictive marker of poor prognosis in women with high-risk breast cancer.". Clin. Cancer Res. 10 (18 Pt 1): 6039–46. doi:10.1158/1078-0432.CCR-03-0453. PMID 15447988. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• O'Brien NA, O'Donovan N, Ryan B, et al. (2005). "Mammaglobin a in breast cancer: existence of multiple molecular forms.". Int. J. Cancer 114 (4): 623–7. doi:10.1002/ijc.20780. PMID 15609337. 
• Roncella S, Ferro P, Bacigalupo B, et al. (2005). "Human mammaglobin mRNA is a reliable molecular marker for detecting occult breast cancer cells in peripheral blood.". J. Exp. Clin. Cancer Res. 24 (2): 265–71. PMID 16110760. 
• Span PN, Sweep FC (2006). "Mammaglobin as molecular marker of breast cancer (micro)metastases.". Clin. Cancer Res. 11 (19 Pt 1): 7043; author reply 7044. doi:10.1158/1078-0432.CCR-05-1378. PMID 16203799. 
• Roncella S, Ferro P, Bacigalupo B, et al. (2006). "Relationship between human mammaglobin mRNA expression in breast cancer tissue and clinico-pathologic features of the tumors.". J. Exp. Clin. Cancer Res. 25 (1): 65–72. PMID 16761620. 
• Ntoulia M, Stathopoulou A, Ignatiadis M, et al. (2007). "Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR.". Clin. Biochem. 39 (9): 879–87. doi:10.1016/j.clinbiochem.2006.06.009. PMID 16925986. 
• Gimbergues P, Dauplat MM, Cayre A, et al. (2007). "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category.". Eur J Surg Oncol 33 (1): 16–22. doi:10.1016/j.ejso.2006.09.013. PMID 17071045. 
• Sasaki E, Tsunoda N, Hatanaka Y, et al. (2007). "Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers.". Mod. Pathol. 20 (2): 208–14. doi:10.1038/modpathol.3800731. PMID 17192791.