SCGB3A2
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| Secretoglobin, family 3A, member 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SCGB3A2; LU103; PNSP1; UGRP1; pnSP-1 | ||||||||||
| External IDs | OMIM: 606531 MGI: 2153470 HomoloGene: 14274 GeneCards: SCGB3A2 Gene | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 117156 | 117158 | |||||||||
| Ensembl | ENSG00000164265 | ENSMUSG00000038791 | |||||||||
| UniProt | Q96PL1 | Q5D060 | |||||||||
| RefSeq (mRNA) | NM_054023 | NM_054038.1 | |||||||||
| RefSeq (protein) | NP_473364 | NP_473379.1 | |||||||||
| Location (UCSC) | Chr 5: 147.25 – 147.26 Mb |
Chr 18: 43.92 – 43.93 Mb |
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| PubMed search | [1] | [2] | |||||||||
Secretoglobin family 3A member 2 is a protein that in humans is encoded by the SCGB3A2 gene.[1][2]
In addition to regulating thyroid-specific expression of genes, thyroid transcription factor (TITF1; MIM 600635) controls the transcription of genes specifically expressed in lung, such as surfactant proteins (e.g., SFTPA1; MIM 178630) and uteroglobin (UGB; MIM 192020). Mice lacking Ttf1 die immediately after birth from respiratory failure caused by profoundly hypoplastic lungs (Kimura et al., 1996). The UGRP1 gene encodes a uteroglobin-related protein and is a downstream target of TITF1.[supplied by OMIM][2]
[edit] References
- ^ Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S (Oct 2001). "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor". Mol Endocrinol 15 (11): 2021–36. doi:10.1210/me.15.11.2021. PMID 11682631.
- ^ a b "Entrez Gene: SCGB3A2 secretoglobin, family 3A, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117156.
[edit] Further reading
- Kimura S, Hara Y, Pineau T, et al. (1996). "The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary". Genes Dev. 10 (1): 60–9. doi:10.1101/gad.10.1.60. PMID 8557195.
- Wattiez R, Hermans C, Cruyt C, et al. (2001). "Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases". Electrophoresis 21 (13): 2703–12. doi:10.1002/1522-2683(20000701)21:13<2703::AID-ELPS2703>3.0.CO;2-W. PMID 10949149.
- Niimi T, Munakata M, Keck-Waggoner CL, et al. (2002). "A Polymorphism in the Human UGRP1 Gene Promoter That Regulates Transcription Is Associated with an Increased Risk of Asthma". Am. J. Hum. Genet. 70 (3): 718–25. doi:10.1086/339272. PMC 384948. PMID 11813133. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384948.
- Porter D, Lahti-Domenici J, Torres-Arzayus M, et al. (2003). "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues". Mech. Dev. 114 (1–2): 201–4. doi:10.1016/S0925-4773(02)00056-4. PMID 12175512.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bin LH, Nielson LD, Liu X, et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair". J. Immunol. 171 (2): 924–30. PMID 12847263.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Srisodsai A, Kurotani R, Chiba Y, et al. (2005). "Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1". J. Biol. Chem. 279 (52): 54358–68. doi:10.1074/jbc.M405331200. PMID 15485815.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
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