SCN1B

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Sodium channel, voltage-gated, type I, beta subunit
Identifiers
Symbols SCN1B ; GEFSP1
External IDs OMIM600235 MGI98247 HomoloGene810 ChEMBL: 5487 GeneCards: SCN1B Gene
RNA expression pattern
PBB GE SCN1B 205508 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6324 20266
Ensembl ENSG00000105711 ENSMUSG00000019194
UniProt Q07699 P97952
RefSeq (mRNA) NM_001037 NM_011322
RefSeq (protein) NP_001028 NP_035452
Location (UCSC) Chr 19:
35.52 – 35.53 Mb
Chr 7:
31.12 – 31.13 Mb
PubMed search [1] [2]

Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.[1][2]

Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM][2]

Clinical significance[edit]

Mutation in the SCN1B gene are associated with Brugada syndrome.

See also[edit]

References[edit]

  1. ^ McClatchey AI, Cannon SC, Slaugenhaupt SA, Gusella JF (Sep 1993). "The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain". Hum Mol Genet 2 (6): 745–9. doi:10.1093/hmg/2.6.745. PMID 8394762. 
  2. ^ a b "Entrez Gene: SCN1B sodium channel, voltage-gated, type I, beta". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.