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Sodium channel, voltage-gated, type III, alpha subunit
Protein SCN3A PDB 1byy.png
PDB rendering based on 1byy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SCN3A ; NAC3; Nav1.3
External IDs OMIM182391 MGI98249 HomoloGene56005 IUPHAR: 580 ChEMBL: 5163 GeneCards: SCN3A Gene
RNA expression pattern
PBB GE SCN3A 210432 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6328 20269
Ensembl ENSG00000153253 ENSMUSG00000057182
UniProt Q9NY46 A2ASI4
RefSeq (mRNA) NM_001081676 NM_018732
RefSeq (protein) NP_001075145 NP_061202
Location (UCSC) Chr 2:
165.94 – 166.06 Mb
Chr 2:
65.46 – 65.57 Mb
PubMed search [1] [2]

Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the Nav1.3 gene.[1]

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

SCN3A is the only sodium channel transcript which is changed after nerve injury.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.