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Sodium channel, non-voltage-gated 1 alpha subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SCNN1A ; BESC2; ENaCa; ENaCalpha; SCNEA; SCNN1
External IDs OMIM600228 MGI101782 HomoloGene811 IUPHAR: ENaC α ChEMBL: 1791 GeneCards: SCNN1A Gene
RNA expression pattern
PBB GE SCNN1A 203453 at tn.png
PBB GE SCNN1A 215026 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6337 20276
Ensembl ENSG00000111319 ENSMUSG00000030340
UniProt P37088 Q61180
RefSeq (mRNA) NM_001038 NM_011324
RefSeq (protein) NP_001029 NP_035454
Location (UCSC) Chr 12:
6.46 – 6.49 Mb
Chr 6:
125.32 – 125.34 Mb
PubMed search [1] [2]

Amiloride-sensitive sodium channel subunit alpha is a protein that in humans is encoded by the SCNN1A gene.[1][2]

See also[edit]


SCNN1A has been shown to interact with NEDD4L,[3][4] Ubiquitin C[5][6] and NEDD4.[3][7][8]


  1. ^ Meisler MH, Barrow LL, Canessa CM, Rossier BC (April 1995). "SCNN1, an epithelial cell sodium channel gene in the conserved linkage group on mouse chromosome 6 and human chromosome 12". Genomics 24 (1): 185–6. doi:10.1006/geno.1994.1599. PMID 7896277. 
  2. ^ "Entrez Gene: SCNN1A sodium channel, nonvoltage-gated 1 alpha". 
  3. ^ a b Harvey, K F; Dinudom A; Cook D I; Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. (United States) 276 (11): 8597–601. doi:10.1074/jbc.C000906200. ISSN 0021-9258. PMID 11244092. 
  4. ^ Malbert-Colas, Laurence; Nicolas Gaël; Galand Colette; Lecomte Marie-Christine; Dhermy Didier (July 2003). "Identification of new partners of the epithelial sodium channel alpha subunit". C. R. Biol. (France) 326 (7): 615–24. doi:10.1016/s1631-0691(03)00154-9. ISSN 1631-0691. PMID 14556380. 
  5. ^ Boulkroun, Sheerazed; Ruffieux-Daidié Dorothée, Vitagliano Jean-Jacques, Poirot Olivier, Charles Roch-Philippe, Lagnaz Dagmara, Firsov Dmitri, Kellenberger Stephan, Staub Olivier (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. (United States) 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. ISSN 0363-6127. PMID 18632802. 
  6. ^ Raikwar, Nandita S; Thomas Christie P (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. (United States) 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. ISSN 0363-6127. PMC 2424110. PMID 18322022. 
  7. ^ Farr, T J; Coddington-Lawson S J; Snyder P M; McDonald F J (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. (England). 345 Pt 3 (3): 503–9. doi:10.1042/0264-6021:3450503. ISSN 0264-6021. PMC 1220784. PMID 10642508. 
  8. ^ McDonald, Fiona J; Western Andrea H; McNeil John D; Thomas Brittany C; Olson Diane R; Snyder Peter M (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. (United States) 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. ISSN 0363-6127. PMID 12167593. 

Further reading[edit]

External links[edit]