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Sodium channel, non-voltage-gated 1, beta subunit
Symbols SCNN1B ; BESC1; ENaCb; ENaCbeta; SCNEB
External IDs OMIM600760 MGI104696 HomoloGene133555 IUPHAR: ENaC β ChEMBL: 1628483 GeneCards: SCNN1B Gene
RNA expression pattern
PBB GE SCNN1B 205464 at tn.png
More reference expression data
Species Human Mouse
Entrez 6338 20277
Ensembl ENSG00000168447 ENSMUSG00000030873
UniProt P51168 Q9WU38
RefSeq (mRNA) NM_000336 NM_001272023
RefSeq (protein) NP_000327 NP_001258952
Location (UCSC) Chr 16:
23.29 – 23.39 Mb
Chr 7:
121.87 – 121.92 Mb
PubMed search [1] [2]

Amiloride-sensitive sodium channel beta subunit is one of the three subunits that form the Epithelial sodium channel. In humans this protein is encoded by the SCNN1B gene.[1]

Gene and protein structure[edit]

In the human genome the gene encoding for the beta subunit of ENaC includes 13 exons. Exons 2-13 include the coding region of the gene. The location of the introns in all three genes coding for the three subunits is strictly conserved. The protein sequences of the three subunits show 26-30% sequence identity. [2]


SCNN1B has been shown to interact with WWP2[3][4] and NEDD4.[3][4][5]


  1. ^ "Entrez Gene: SCNN1B sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)". 
  2. ^ Saxena, A.; Hanukoglu, I.; Strautnieks, SS.; Thompson, RJ.; Gardiner, RM.; Hanukoglu, A. (Nov 1998). "Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit.". Biochem Biophys Res Commun 252 (1): 208–13. doi:10.1006/bbrc.1998.9625. PMID 9813171. 
  3. ^ a b McDonald, Fiona J; Western Andrea H; McNeil John D; Thomas Brittany C; Olson Diane R; Snyder Peter M (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. (United States) 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. ISSN 0363-6127. PMID 12167593. 
  4. ^ a b Harvey, K F; Dinudom A; Cook D I; Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. (United States) 276 (11): 8597–601. doi:10.1074/jbc.C000906200. ISSN 0021-9258. PMID 11244092. 
  5. ^ Farr, T J; Coddington-Lawson S J; Snyder P M; McDonald F J (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. (ENGLAND). 345 Pt 3 (3): 503–9. doi:10.1042/0264-6021:3450503. ISSN 0264-6021. PMC 1220784. PMID 10642508. 

Further reading[edit]

External links[edit]