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Sodium channel, non-voltage-gated 1, gamma subunit
Symbols SCNN1G ; BESC3; ENaCg; ENaCgamma; PHA1; SCNEG
External IDs OMIM600761 MGI104695 HomoloGene20280 IUPHAR: ENaC γ ChEMBL: 1628484 GeneCards: SCNN1G Gene
Species Human Mouse
Entrez 6340 20278
Ensembl ENSG00000166828 ENSMUSG00000000216
UniProt P51170 Q9WU39
RefSeq (mRNA) NM_001039 NM_011326
RefSeq (protein) NP_001030 NP_035456
Location (UCSC) Chr 16:
23.19 – 23.23 Mb
Chr 7:
121.73 – 121.77 Mb
PubMed search [1] [2]

Amiloride-sensitive sodium channel subunit gamma is a protein that in humans is encoded by the SCNN1G gene.[1][2]

See also[edit]


SCNN1G has been shown to interact with STX1A,[3] Ubiquitin C[4][5] and NEDD4.[6][7][8]


  1. ^ Voilley N, Bassilana F, Mignon C, Merscher S, Mattei MG, Carle GF, Lazdunski M, Barbry P (January 1996). "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel". Genomics 28 (3): 560–5. doi:10.1006/geno.1995.1188. PMID 7490094. 
  2. ^ "Entrez Gene: SCNN1G sodium channel, nonvoltage-gated 1, gamma". 
  3. ^ Berdiev, Bakhrom K; Jovov Biljana; Tucker Ward C; Naren Anjaparavanda P; Fuller Catherine M; Chapman Edwin R; Benos Dale J (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. (United States) 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. ISSN 0363-6127. PMID 14996668. 
  4. ^ Boulkroun, Sheerazed; Ruffieux-Daidié Dorothée, Vitagliano Jean-Jacques, Poirot Olivier, Charles Roch-Philippe, Lagnaz Dagmara, Firsov Dmitri, Kellenberger Stephan, Staub Olivier (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. (United States) 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. ISSN 0363-6127. PMID 18632802. 
  5. ^ Raikwar, Nandita S; Thomas Christie P (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. (United States) 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. ISSN 0363-6127. PMC 2424110. PMID 18322022. 
  6. ^ Farr, T J; Coddington-Lawson S J; Snyder P M; McDonald F J (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. (England) 345 (3): 503–9. doi:10.1042/0264-6021:3450503. ISSN 0264-6021. PMC 1220784. PMID 10642508. 
  7. ^ McDonald, Fiona J; Western Andrea H; McNeil John D; Thomas Brittany C; Olson Diane R; Snyder Peter M (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. (United States) 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. ISSN 0363-6127. PMID 12167593. 
  8. ^ Harvey, K F; Dinudom A; Cook D I; Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. (United States) 276 (11): 8597–601. doi:10.1074/jbc.C000906200. ISSN 0021-9258. PMID 11244092. 

Further reading[edit]

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