From Wikipedia, the free encyclopedia
Jump to: navigation, search
Syndecan binding protein (syntenin)
Protein SDCBP PDB 1n99.png
PDB rendering based on 1n99.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SDCBP ; MDA-9; ST1; SYCL; TACIP18
External IDs OMIM602217 MGI1337026 HomoloGene4110 GeneCards: SDCBP Gene
RNA expression pattern
PBB GE SDCBP 200958 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6386 53378
Ensembl ENSG00000137575 ENSMUSG00000028249
UniProt O00560 O08992
RefSeq (mRNA) NM_001007067 NM_001098227
RefSeq (protein) NP_001007068 NP_001091697
Location (UCSC) Chr 8:
59.47 – 59.5 Mb
Chr 4:
6.37 – 6.41 Mb
PubMed search [1] [2]

Syntenin-1 is a protein that in humans is encoded by the SDCBP gene.[1]

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]


SDCBP has been shown to interact with Merlin,[3] ULK1,[4] Interleukin 5 receptor alpha subunit,[5] SOX4,[5] RAB5A,[4] EFNB1,[6] TRAF6,[7] GRIK1[8] and GRIK2.[8][9]


  1. ^ Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J, David G (January 1998). "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains". Proc Natl Acad Sci USA 94 (25): 13683–8. doi:10.1073/pnas.94.25.13683. PMC 28366. PMID 9391086. 
  2. ^ "Entrez Gene: SDCBP syndecan binding protein (syntenin)". 
  3. ^ Jannatipour, M; Dion P; Khan S; Jindal H; Fan X; Laganière J; Chishti A H; Rouleau G A (August 2001). "Schwannomin isoform-1 interacts with syntenin via PDZ domains". J. Biol. Chem. (United States) 276 (35): 33093–100. doi:10.1074/jbc.M105792200. ISSN 0021-9258. PMID 11432873. 
  4. ^ a b Tomoda, Toshifumi; Kim Jee Hae; Zhan Caixin; Hatten Mary E (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. (United States) 18 (5): 541–58. doi:10.1101/gad.1151204. ISSN 0890-9369. PMC 374236. PMID 15014045. 
  5. ^ a b Geijsen, N; Uings I J; Pals C; Armstrong J; McKinnon M; Raaijmakers J A; Lammers J W; Koenderman L; Coffer P J (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science (United States) 293 (5532): 1136–8. doi:10.1126/science.1059157. ISSN 0036-8075. PMID 11498591. 
  6. ^ Lin, D; Gish G D; Songyang Z; Pawson T (February 1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif". J. Biol. Chem. (UNITED STATES) 274 (6): 3726–33. doi:10.1074/jbc.274.6.3726. ISSN 0021-9258. PMID 9920925. 
  7. ^ Chen, Fang; Du Yijuan; Zhang Zheng; Chen Gang; Zhang Min; Shu Hong-Bing; Zhai Zhonghe; Chen Danying (April 2008). "Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling". Cell. Signal. (England) 20 (4): 666–74. doi:10.1016/j.cellsig.2007.12.002. ISSN 0898-6568. PMID 18234474. 
  8. ^ a b Hirbec, Hélène; Francis Joanna C, Lauri Sari E, Braithwaite Steven P, Coussen Françoise, Mulle Christophe, Dev Kumlesh K, Coutinho Victoria, Meyer Guido, Isaac John T R, Collingridge Graham L, Henley Jeremy M, Couthino Victoria (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron (United States) 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. ISSN 0896-6273. PMC 3314502. PMID 12597860. 
  9. ^ Hirbec, Hélène; Perestenko Olga; Nishimune Atsushi; Meyer Guido; Nakanishi Shigetada; Henley Jeremy M; Dev Kumlesh K (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. (United States) 277 (18): 15221–4. doi:10.1074/jbc.C200112200. ISSN 0021-9258. PMID 11891216. 

Further reading[edit]