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Sidekick cell adhesion molecule 2
Protein SDK2 PDB 1wf5.png
PDB rendering based on 1wf5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SDK2 ; FLJ10832; KIAA1514
External IDs OMIM607217 MGI2443847 HomoloGene10406 GeneCards: SDK2 Gene
RNA expression pattern
PBB GE SDK2 220628 s at tn.png
PBB GE SDK2 gnf1h03181 at tn.png
More reference expression data
Species Human Mouse
Entrez 54549 237979
Ensembl ENSG00000069188 ENSMUSG00000041592
UniProt Q58EX2 Q6V4S5
RefSeq (mRNA) NM_001144952 NM_172800
RefSeq (protein) NP_001138424 NP_766388
Location (UCSC) Chr 17:
71.33 – 71.64 Mb
Chr 11:
113.78 – 114.07 Mb
PubMed search [1] [2]
For the Japanese game, see Super Donkey Kong 2

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.[1][2][3]

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.[3]


  1. ^ Yamagata M, Weiner JA, Sanes JR (Sep 2002). "Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina". Cell 110 (5): 649–60. doi:10.1016/S0092-8674(02)00910-8. PMID 12230981. 
  2. ^ Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (Jun 2004). "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J Am Soc Nephrol 15 (7): 1721–30. doi:10.1097/01.ASN.0000128975.28958.C2. PMID 15213259. 
  3. ^ a b "Entrez Gene: SDK2 sidekick homolog 2 (chicken)". 

Further reading[edit]