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SEC14-like 2 (S. cerevisiae)
Protein SEC14L2 PDB 1o6u.png
PDB rendering based on 1o6u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SEC14L2 ; C22orf6; SPF; TAP; TAP1
External IDs OMIM607558 MGI1915065 HomoloGene8245 GeneCards: SEC14L2 Gene
RNA expression pattern
PBB GE SEC14L2 204541 at tn.png
More reference expression data
Species Human Mouse
Entrez 23541 67815
Ensembl ENSG00000100003 ENSMUSG00000003585
UniProt O76054 Q99J08
RefSeq (mRNA) NM_001204204 NM_144520
RefSeq (protein) NP_001191133 NP_653103
Location (UCSC) Chr 22:
30.79 – 30.82 Mb
Chr 11:
4.1 – 4.12 Mb
PubMed search [1] [2]

SEC14-like protein 2 is a protein that in humans is encoded by the SEC14L2 gene.[1][2]

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway.[2]


  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ a b "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)". 

Further reading[edit]