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SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
Protein SEC22B PDB 1ifq.png
PDB rendering based on 1ifq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SEC22B ; ERS-24; SEC22L1
External IDs OMIM604029 MGI1338759 HomoloGene3597 GeneCards: SEC22B Gene
Species Human Mouse
Entrez 9554 20333
Ensembl ENSG00000265808 ENSMUSG00000027879
UniProt O75396 O08547
RefSeq (mRNA) NM_004892 NM_011342
RefSeq (protein) NP_004883 NP_035472
Location (UCSC) Chr HG1292_PATCH:
120.7 – 120.72 Mb
Chr 3:
97.9 – 97.92 Mb
PubMed search [1] [2]

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.[1][2][3]

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript.[3] SEC22B has been shown to interact with syntaxin 18.


  1. ^ Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. 
  2. ^ Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (Feb 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J Biol Chem 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670. 
  3. ^ a b "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)". 

Further reading[edit]