The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It contains a gelsolin domain. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
Sec23 has also been shown to interact with TRAPPⅠ, Grh1p also known as GRASP65 and Dynactin. Because they are involved in anterograde vesicle transport from ER to Golgi, Sec23 is involved in vesicle transport.
^Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton70 (11): 775–95. doi:10.1002/cm.21149. PMID24155256.edit
^Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Mar 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem.274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID10075675.
^p125 is localized in endoplasmic reticulum exit sites and involved in their organization.
^Coordination of COPII vesicle trafficking by Sec23.
Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem.274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID10075675.
Tang BL, Kausalya J, Low DY, Lock ML, Hong W (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun.258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID10329445.
Boyadjiev SA, Justice CM, Eyaid W, McKusick VA, Lachman RS, Chowdry AB et al. (2003). "A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21". Hum. Genet.113 (1): 1–9. doi:10.1007/s00439-003-0932-6. PMID12677423.
Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP (2004). "Regulation of a COPII component by cytosolic O-glycosylation during mitosis". FEBS Lett.561 (1-3): 44–50. doi:10.1016/S0014-5793(04)00109-7. PMID15013749.
Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell. Sci.118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID16091426.
Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ et al. (2006). "Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking". Nat. Genet.38 (10): 1192–7. doi:10.1038/ng1876. PMID16980979.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell Proteomics6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID17220478.