From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sec23 homolog B (S. cerevisiae)
External IDs OMIM610512 MGI1350925 HomoloGene74571 GeneCards: SEC23B Gene
RNA expression pattern
PBB GE SEC23B 210293 s at tn.png
PBB GE SEC23B 201582 at tn.png
PBB GE SEC23B 201583 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10483 27054
Ensembl ENSG00000101310 ENSMUSG00000027429
UniProt Q15437 Q9D662
RefSeq (mRNA) NM_001172745 NM_001252543
RefSeq (protein) NP_001166216 NP_001239472
Location (UCSC) Chr 20:
18.51 – 18.56 Mb
Chr 2:
144.56 – 144.59 Mb
PubMed search [1] [2]

Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.[1][2][3]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[3] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).


  1. ^ Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360. 
  2. ^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445. 
  3. ^ a b "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)". 

Further reading[edit]