The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.
^Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID10329445.
Pagano A, Letourneur F, Garcia-Estefania D et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum.". J. Biol. Chem.274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID10075675.CS1 maint: Explicit use of et al. (link)
Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.CS1 maint: Explicit use of et al. (link)
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.CS1 maint: Explicit use of et al. (link)