From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Symbols SEMA3B ; LUCA-1; SEMA5; SEMAA; SemA; semaV
External IDs OMIM601281 MGI107561 HomoloGene20972 GeneCards: SEMA3B Gene
RNA expression pattern
PBB GE SEMA3B 203071 at tn.png
More reference expression data
Species Human Mouse
Entrez 7869 20347
Ensembl ENSG00000012171 ENSMUSG00000057969
UniProt Q13214 Q62177
RefSeq (mRNA) NM_001005914 NM_001042779
RefSeq (protein) NP_001005914 NP_001036244
Location (UCSC) Chr 3:
50.27 – 50.28 Mb
Chr 9:
107.6 – 107.61 Mb
PubMed search [1] [2]

Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.[1][2][3]

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.[3]


  1. ^ Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561. 
  2. ^ Sekido Y, Bader S, Latif F, Chen JY, Duh FM, Wei MH, Albanesi JP, Lee CC, Lerman MI, Minna JD (Jul 1996). "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns". Proc Natl Acad Sci U S A 93 (9): 4120–5. doi:10.1073/pnas.93.9.4120. PMC 39497. PMID 8633026. 
  3. ^ a b "Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B". 

Further reading[edit]