SEMA3F

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Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Identifiers
Symbols SEMA3F ; SEMA-IV; SEMA4; SEMAK
External IDs OMIM601124 MGI1096347 HomoloGene20885 GeneCards: SEMA3F Gene
RNA expression pattern
PBB GE SEMA3F 35666 at tn.png
PBB GE SEMA3F 206832 s at tn.png
PBB GE SEMA3F 209730 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6405 20350
Ensembl ENSG00000001617 ENSMUSG00000034684
UniProt Q13275 O88632
RefSeq (mRNA) NM_004186 NM_011349
RefSeq (protein) NP_004177 NP_035479
Location (UCSC) Chr 3:
50.19 – 50.23 Mb
Chr 9:
107.68 – 107.71 Mb
PubMed search [1] [2]

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.[1][2][3]

The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM][3]

References[edit]

  1. ^ Xiang RH, Hensel CH, Garcia DK, Carlson HC, Kok K, Daly MC, Kerbacher K, van den Berg A, Veldhuis P, Buys CH, Naylor SL (Sep 1996). "Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer". Genomics 32 (1): 39–48. doi:10.1006/geno.1996.0074. PMID 8786119. 
  2. ^ Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, Swanton M, Waggoner B, Fishel R, Franklin W, Gemmill R, Drabkin H (Jul 1996). "Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin". Oncogene 12 (6): 1289–97. PMID 8649831. 
  3. ^ a b "Entrez Gene: SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F". 

Further reading[edit]