SEMA4G

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Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Identifiers
Symbols SEMA4G ; FLJ20590; KIAA1619; MGC102867
External IDs MGI1347047 HomoloGene22682 GeneCards: SEMA4G Gene
RNA expression pattern
PBB GE SEMA4G 219194 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57715 26456
Ensembl ENSG00000095539 ENSMUSG00000025207
UniProt Q9NTN9 Q9WUH7
RefSeq (mRNA) NM_001203244 NM_011976
RefSeq (protein) NP_001190173 NP_036106
Location (UCSC) Chr 10:
102.73 – 102.75 Mb
Chr 19:
44.99 – 45 Mb
PubMed search [1] [2]

Semaphorin-4G is a protein that in humans is encoded by the SEMA4G gene.[1]

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.[1]

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