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Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Symbols SEMA4G ; FLJ20590; KIAA1619; MGC102867
External IDs MGI1347047 HomoloGene22682 GeneCards: SEMA4G Gene
RNA expression pattern
PBB GE SEMA4G 219194 at tn.png
More reference expression data
Species Human Mouse
Entrez 57715 26456
Ensembl ENSG00000095539 ENSMUSG00000025207
UniProt Q9NTN9 Q9WUH7
RefSeq (mRNA) NM_001203244 NM_011976
RefSeq (protein) NP_001190173 NP_036106
Location (UCSC) Chr 10:
102.73 – 102.75 Mb
Chr 19:
44.99 – 45 Mb
PubMed search [1] [2]

Semaphorin-4G is a protein that in humans is encoded by the SEMA4G gene.[1]

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.[1]


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