SEMA5A

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Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Identifiers
Symbols SEMA5A ; SEMAF; semF
External IDs OMIM609297 MGI107556 HomoloGene2949 GeneCards: SEMA5A Gene
RNA expression pattern
PBB GE SEMA5A 205405 at tn.png
PBB GE SEMA5A 213169 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9037 20356
Ensembl ENSG00000112902 ENSMUSG00000022231
UniProt Q13591 E9PWW3
RefSeq (mRNA) NM_003966 NM_009154
RefSeq (protein) NP_003957 NP_033180
Location (UCSC) Chr 5:
9.04 – 9.55 Mb
Chr 15:
32.24 – 32.7 Mb
PubMed search [1] [2]

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[1][2][3]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][3]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (needs citation).

References[edit]

  1. ^ Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451. 
  2. ^ Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278. 
  3. ^ a b "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A". 

Further reading[edit]