Dasotraline

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Dasotraline
Dasotraline.svg
Systematic (IUPAC) name
(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
Clinical data
Identifiers
675126-05-3
PubChem CID 9947999
ChemSpider 8123611 N
Chemical data
Formula C16H15Cl2N
 N (what is this?)  (verify)

Dasotraline (INN;[1] SEP-225,289) is an antidepressant drug, which was being developed by Sepracor. It is a so-called triple reuptake inhibitor (TRI).[2][3][4][5]

ADHD study[edit]

Clinical trials are being conducted to determine the efficacy and safety of dasotraline in adults with ADHD.[6]

References[edit]

  1. ^ "WHO Drug Information, Vol. 27, No. 4, 2013 Proposed INN: List 110" (PDF). WHO. Retrieved 4 November 2014. 
  2. ^ Chen Z, Skolnick P (September 2007). "Triple uptake inhibitors: therapeutic potential in depression and beyond". Expert Opin Investig Drugs 16 (9): 1365–77. doi:10.1517/13543784.16.9.1365. PMID 17714023. 
  3. ^ DeLorenzo C, Lichenstein S, Schaefer K, Dunn J, Marshall R, Organisak L, Kharidia J, Robertson B, Mann JJ, Parsey RV (July 2011). "SEP-225289 serotonin and dopamine transporter occupancy: a PET study". J. Nucl. Med. 52 (7): 1150–5. doi:10.2967/jnumed.110.084525. PMC 3856248. PMID 21680689. 
  4. ^ Ziegler, L.; Küffer, G.; Euler, E.; Wilhelm, K. (1990). "Arthrographic imaging of ganglions of the hand". RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 153 (2): 143–146. doi:10.1055/s-2008-1033352. PMID 2168068.  edit
  5. ^ Guiard, B. (2009). "P.1.c.059 Electrophysiological properties of the triple reuptake inhibitor SEP 225289 on monoaminergic neurons". European Neuropsychopharmacology 19: S285. doi:10.1016/S0924-977X(09)70419-5.  edit
  6. ^ "Dasotraline Adult ADHD Study". U.S. National Institutes of Health. Retrieved February 13, 2015. 

Further reading[edit]

Liming Shao Patent
  • US application 2007203111, Shao L, Wang F, Malcolm SC, Hewitt MC, Bush LR, Ma J, Varney MA, Campbell U, Engel SR, Hardy LW, Koch P, Campbell JE, "Cycloalkylamines as monoamine reuptake inhibitors", published 2007-08-30, assigned to Sepracor Inc. 
Asymmetry Patent
  • US patent 7129378, Han X, Krishnamurthy D, Senanayake CH, Lu Z-H, "Method of preparing amine stereoisomers", published 2005-07-28, assigned to Apsinterm LLC